Cell Biology

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

1. Manuela Richter
2. Lila Neahring
3. Jinghui Tao
4. Renaldo Sutanto
5. Nathan H Cho
6. Sophie Dumont

• Curated by eLife

  eLife assessment

  The authors compellingly demonstrate that k-fiber length and dynamics are regulated at the level of individual fibers, even in the absence of focused poles, but that unfocused spindles fail to accurately segregate chromosomes, suggesting that coordination of k-fiber length by pole focusing is important for spindle function. This study provides important new information on spindle scaling, extending in an original manner previous work on this topic.

Reviewed by eLife

Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice

1. Yuqi Guo
2. Jianlu Wei
3. Chuanju Liu
4. Xin Li
5. Wenbo Yan

• Curated by eLife

  eLife assessment

  This fundamental work advances our understanding of the effects of metformin on bone healing in hyperglycemic conditions. The evidence supporting the conclusion is convincing, using three different types of bone fracture models in type-2 diabetes (T2D) mice. This paper is of potential interest to skeletal biologists, orthopaedic surgeons, and endocrinologists who study the effects of metformin on fracture healing.

Reviewed by eLife

Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development

1. Anna R. Yeh
2. Gregory J. Hoeprich
3. Anthony D. McDougal
4. Bruce L. Goode
5. Adam C. Martin

Reviewed by Review Commons

A simple Turing reaction-diffusion model can explain how mother centrioles break symmetry to generate a single daughter

1. Zachary M. Wilmott
2. Alain Goriely
3. Jordan W. Raff

Reviewed by Review Commons

GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

1. Gaoran Ge
2. Qianping Guo
3. Ying Zhou
4. Wenming Li
5. Wei Zhang
6. Jiaxiang Bai
7. Qing Wang
8. Huaqiang Tao
9. Wei Wang
10. Zhen Wang
11. Minfeng Gan
12. Yaozeng Xu
13. Huilin Yang
14. Bin Li
15. Dechun Geng

Reviewed by Review Commons

Distinct role of TGN-resident clathrin adaptors for Rab5 activation in the TGN-endosome trafficking pathway

1. Makoto Nagano
2. Kaito Aoshima
3. Hiroki Shimamura
4. Daria Elisabeth Siekhaus
5. Junko Y. Toshima
6. Jiro Toshima

Reviewed by Review Commons

Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast

1. John-Patrick Alao
2. Juhi Kumar
3. Despina Stamataki
4. Charalampos Rallis

Reviewed by Review Commons

Genome-scale requirements for dynein-based trafficking revealed by a high-content arrayed CRISPR screen

1. Chun Hao Wong
2. Steven W. Wingett
3. Chen Qian
4. J. Matthew Taliaferro
5. Douglas Ross-Thriepland
6. Simon L. Bullock

Reviewed by Review Commons

Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells

1. Rui Santalla Méndez
2. Andrea Rodgers Furones
3. René Classens
4. Manon Haverdil
5. Marta Canela Capdevila
6. Anne van Duffelen
7. Cornelia G. Spruijt
8. Michiel Vermeulen
9. Martin ter Beest
10. Annemiek B. van Spriel
11. Laia Querol Cano

Reviewed by Review Commons

The ER membrane protein complex governs lysosomal turnover of a mitochondrial tail-anchored protein, BNIP3, to restrict mitophagy

1. Jose M Delgado
2. Logan Wallace Shepard
3. Sarah W Lamson
4. Samantha L Liu
5. Christopher J Shoemaker

Reviewed by Review Commons