Cell Biology

  1. A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

    1. Qin Zou
    2. Rong Yuan
    3. Yu Zhang
    4. Yifei Wang
    5. Ting Zheng
    6. Rui Shi
    7. Mei Zhang
    8. Yujing Li
    9. Kaixin Fei
    10. Ran Feng
    11. Binyun Pan
    12. Xinyue Zhang
    13. Zhengyin Gong
    14. Li Zhu
    15. Guoqing Tang
    16. Mingzhou Li
    17. Xuewei Li
    18. Yanzhi Jiang

    • Curated by eLife

      eLife assessment

      This valuable manuscript provides a single-cell RNA sequencing analysis of adult pig skin from different species and anatomical regions. The evidence supporting the conclusions is compelling, with identification molecular and cellular differences in pig skin, yet the analyses are incomplete in the analysis of regional- or species-based differences.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling

    1. Robert Jackson
    2. Esha V Rajadhyaksha
    3. Reid S Loeffler
    4. Caitlyn E Flores
    5. Koenraad Van Doorslaer

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranes

    1. Vanesa Madan
    2. Lucas Albacete Albacete
    3. Li Jin
    4. Pietro Scaturro
    5. Joseph L. Watson
    6. Nadine Muschalik
    7. Farida Begum
    8. Jérôme Boulanger
    9. Karl Bauer
    10. Michael A. Kiebler
    11. Emmanuel Derivery
    12. Simon L. Bullock

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

    1. Chaojun Yan
    2. Jingjing Xiong
    3. Zirui Zhou
    4. Qifang Li
    5. Chuan Gao
    6. Mengyao Zhang
    7. Liya Yu
    8. Jinpeng Li
    9. Ming-Ming Hu
    10. Chen-Song Zhang
    11. Cheguo Cai
    12. Haojian Zhang
    13. Jing Zhang

    • Curated by eLife

      eLife assessment

      This study presents the valuable finding that a cleaved form of METTL3 (termed METTL3a) has an essential role in regulating the assembly of the METTL3-METTL14-WTAP complex. The evidence supporting the claims of the authors is solid, and the work will be of interest to medical biologists working on breast cancer.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Interplay between PLEKHG3-regulated actin dynamics and lysosomal trafficking in cell motility

    1. Rainer Ettelt
    2. Georg Vucak
    3. Sebastian Didusch
    4. Biljana Riemelmoser
    5. Karin Ehrenreiter
    6. Markus Hartl
    7. Lukas A. Huber
    8. Manuela Baccarini

    Reviewed by Review Commons

    4 evaluationsAppears in 2 listsLatest version Latest activity

  6. CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesis

    1. Melis D. Arslanhan
    2. Emmanuelle Steib
    3. Virginie Hamel
    4. Paul Guichard
    5. Elif Nur Firat-Karalar

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  7. Metabolic rewiring of mitochondria in senescence revealed by time-resolved analysis of the mitochondrial proteome

    1. Jun Yong Kim
    2. Ilian Atanassov
    3. Frederik Dethloff
    4. Lara Kroczek
    5. Thomas Langer

    Reviewed by Review Commons

    4 evaluationsAppears in 2 listsLatest version Latest activity

  8. A novel homeostatic mechanism tunes PI(4,5)P2-dependent signaling at the plasma membrane

    1. Rachel C. Wills
    2. Colleen P. Doyle
    3. James P. Zewe
    4. Jonathan Pacheco
    5. Scott D. Hansen
    6. Gerald R. V. Hammond

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

    1. Roberta Cacioppo
    2. Hesna Begum Akman
    3. Taner Tuncer
    4. Ayse Elif Erson-Bensan
    5. Catherine Lindon

    • Curated by eLife

      eLife assessment

      In this important study, the authors provide compelling evidence that the interplay between alternative polyadenylation (APA) of mRNA encoding Aurora Kinase A (AURKA) and hsa-let-7a miRNA governs AURKA protein levels. The authors show that short 3'UTR isoform of mRNA encoding AURKA is efficiently translated throughout the cell cycle, while the long 3'UTR isoform is suppressed by hsa-let-7a miRNA in a cell cycle-dependent manner. These findings delineate post-transcriptional mechanisms regulating AURKA expression that may be implicated in increase in AURKA protein that is frequently observed across a variety of cancers.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  10. MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion

    1. Andres Goldman
    2. Michael Mullokandov
    3. Yehudit Zaltsman
    4. Limor Regev
    5. Smadar Levin-Zaidman
    6. Atan Gross

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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