Cell Biology

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

1. Elisabeth Jongsma
2. Anita Goyala
3. José Maria Mateos
4. Collin Yvès Ewald

• Curated by eLife

  eLife assessment

  Using a newly developed C. elegans model of Alzheimer's disease that expresses Abeta aggregates extracellularly, the authors provide convincing evidence of a disintegrin and an ortholog of human ADAM9 that participate in removing these extracellular aggregates. The worm model presented in this important paper may be very useful to the Alzheimer Disease field.

Reviewed by eLife

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

1. Maikel Castellano-Pozo
2. Georgios Sioutas
3. Consuelo Barroso
4. Josh P Prince
5. Pablo Lopez-Jimenez
6. Joseph Davy
7. Angel-Luis Jaso-Tamame
8. Oliver Crawley
9. Nan Shao
10. Jesus Page
11. Enrique Martinez-Perez

• Curated by eLife

  eLife assessment

  This important paper reveals distinct dynamics of two meiosis-specific cohesin complexes containing either REC-8 or CHO-3/4 in C. elegans: REC-8-cohesin is essential for sister chromatid cohesion in meiosis I and DNA double-strand break repair, while COH-3/4-cohesin, whose binding to meiotic chromosomes is stabilized by the cohesin accessory protein SCC-2, is necessary for loop-axis formation. The experimental evidence in the paper is solid based on cytological analysis using a conditional depletion of the gene. The work will be of interest to researchers working on meiosis and chromosome dynamics.

Reviewed by eLife

Centriole elimination during C. elegans oogenesis initiates with loss of the central tube protein SAS-1

1. Marie Pierron
2. Alexander Woglar
3. Coralie Busso
4. Keshav Jha
5. Tamara Mikeladze-Dvali
6. Marie Croisier
7. Pierre Gönczy

Reviewed by Review Commons

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

1. Avi J. Samelson
2. Nabeela Ariqat
3. Justin McKetney
4. Gita Rohanitazangi
5. Celeste Parra Bravo
6. Rudra Bose
7. Kyle J. Travaglini
8. Victor L. Lam
9. Darrin Goodness
10. Gary Dixon
11. Emily Marzette
12. Julianne Jin
13. Ruilin Tian
14. Eric Tse
15. Romany Abskharon
16. Henry Pan
17. Emma C. Carroll
18. Rosalie E. Lawrence
19. Jason E. Gestwicki
20. Jessica E. Rexach
21. David Eisenberg
22. Nicholas M. Kanaan
23. Daniel R. Southworth
24. John D. Gross
25. Li Gan
26. Danielle L. Swaney
27. Martin Kampmann

Reviewed by preLights

Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2

1. Jeonghwan Youk
2. Taewoo Kim
3. Kelly V. Evans
4. Young-Il Jeong
5. Yongsuk Hur
6. Seon Pyo Hong
7. Je Hyoung Kim
8. Kijong Yi
9. Su Yeon Kim
10. Kwon Joong Na
11. Thomas Bleazard
12. Ho Min Kim
13. Mick Fellows
14. Krishnaa T. Mahbubani
15. Kourosh Saeb-Parsy
16. Seon Young Kim
17. Young Tae Kim
18. Gou Young Koh
19. Byeong-Sun Choi
20. Young Seok Ju
21. Joo-Hyeon Lee

Reviewed by ScreenIT

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

1. Claudia Pommerenke
2. Ulfert Rand
3. Cord C. Uphoff
4. Stefan Nagel
5. Margarete Zaborski
6. Vivien Hauer
7. Maren Kaufmann
8. Corinna Meyer
9. Sabine A. Denkmann
10. Peggy Riese
11. Kathrin Eschke
12. Yeonsu Kim
13. Zeljka Macak Safranko
14. Ivan-Christian Kurolt
15. Alemka Markotic
16. Luka Cicin-Sain
17. Laura Steenpass

Reviewed by ScreenIT

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

1. Emma L. Robinson
2. Kanar Alkass
3. Olaf Bergmann
4. Janet J. Maguire
5. H. Llewelyn Roderick
6. Anthony P. Davenport

Reviewed by ScreenIT

Single-cell transcriptional atlas of the Chinese horseshoe bat ( Rhinolophus sinicus ) provides insight into the cellular mechanisms which enable bats to be viral reservoirs

1. Lili Ren
2. Chao Wu
3. Li Guo
4. Jiacheng Yao
5. Conghui Wang
6. Yan Xiao
7. Angela Oliveira Pisco
8. Zhiqiang Wu
9. Xiaobo Lei
10. Yiwei Liu
11. Leisheng Shi
12. Lianlian Han
13. Hu Zhang
14. Xia Xiao
15. Jingchuan Zhong
16. Hongping Wu
17. Mingkun Li
18. Stephen R. Quake
19. Yanyi Huang
20. Jianbin Wang
21. Jianwei Wang

Reviewed by ScreenIT

SARS-CoV-2 infection and replication in human gastric organoids

1. Giovanni Giuseppe Giobbe
2. Francesco Bonfante
3. Brendan C. Jones
4. Onelia Gagliano
5. Camilla Luni
6. Elisa Zambaiti
7. Silvia Perin
8. Cecilia Laterza
9. Georg Busslinger
10. Hannah Stuart
11. Matteo Pagliari
12. Alessio Bortolami
13. Eva Mazzetto
14. Anna Manfredi
15. Chiara Colantuono
16. Lucio Di Filippo
17. Alessandro Filippo Pellegata
18. Valentina Panzarin
19. Nikhil Thapar
20. Vivian Sze Wing Li
21. Simon Eaton
22. Davide Cacchiarelli
23. Hans Clevers
24. Nicola Elvassore
25. Paolo De Coppi

Reviewed by ScreenIT

The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization†

1. Sangappa B Chadchan
2. Pooja Popli
3. Vineet K Maurya
4. Ramakrishna Kommagani

Reviewed by ScreenIT