Cell Biology

Super-resolution imaging uncovers the nanoscopic segregation of polarity proteins in epithelia

1. Pierre Mangeol
2. Dominique Massey-Harroche
3. Fabrice Richard
4. Jean-Paul Concordet
5. Pierre-François Lenne
6. André Le Bivic

Reviewed by eLife

Identification of a new regulation pathway of EGFR and E-cadherin dynamics

1. Veronique Proux-Gillardeaux
2. Tamara Advedissian
3. Charlotte Perin
4. Jean-Christophe Gelly
5. Mireille Viguier
6. Fredérique Deshayes

Reviewed by eLife

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin stability

1. Fernando R. Balestra
2. Benita Wolf
3. Andrés Domínguez-Calvo
4. Alizée Buff
5. Tessa Averink
6. Marita Lipsanen-Nyman
7. Coralie Busso
8. Pablo Huertas
9. Rosa M. Ríos
10. Pierre Gönczy

Reviewed by Review Commons

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

1. Andrea Serra-Marques
2. Maud Martin
3. Eugene A. Katrukha
4. Ilya Grigoriev
5. Cathelijn A.E. Peeters
6. Qingyang Liu
7. Peter Jan Hooikaas
8. Yao Yao
9. Veronika Solianova
10. Ihor Smal
11. Lotte B. Pedersen
12. Erik Meijering
13. Lukas C. Kapitein
14. Anna Akhmanova

Reviewed by eLife

CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

1. Marrit Putker
2. David Wong
3. Estere Seinkmane
4. Nina Marie Rzechorzek
5. Aiwei Zeng
6. Nathaniel P. Hoyle
7. Johanna E. Chesham
8. Mathew D. Edwards
9. Kevin A. Feeney
10. Robin Fischer
11. Nicolai Peschel
12. Ko-Fan Chen
13. Christopher P. Selby
14. Aziz Sancar
15. John S. O’Neill

Reviewed by Review Commons

Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state

1. Sapan Borah
2. David J. Thaller
3. Zhanna Hakhverdyan
4. Elisa C. Rodriguez
5. Michael P. Rout
6. Megan C. King
7. C. Patrick Lusk

Reviewed by Review Commons

Viral manipulation of mechanoresponsive signaling disassembles processing bodies

1. Elizabeth L. Castle
2. Carolyn-Ann Robinson
3. Pauline Douglas
4. Kristina D. Rinker
5. Jennifer A. Corcoran

Reviewed by eLife

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans without its KASH or actin-binding domains

1. Hongyan Hao
2. Shilpi Kalra
3. Laura E. Jameson
4. Leslie A. Guerrero
5. Natalie E. Cain
6. Jessica Bolivar
7. Daniel A. Starr

Reviewed by eLife

High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

1. Xiaowei Yan
2. Nico Stuurman
3. Susana A. Ribeiro
4. Marvin E. Tanenbaum
5. Max A. Horlbeck
6. Christina R. Liem
7. Marco Jost
8. Jonathan S. Weissman
9. Ronald D. Vale

Reviewed by Review Commons, preLights

Quantitative live-cell imaging and computational modelling yield novel insight into endogenous WNT/CTNNB1 signaling dynamics

1. S.M.A. de Man
2. G. Zwanenburg
3. T. van der Wal
4. M.A. Hink
5. R. van Amerongen

• Curated by eLife

  Evaluation Summary:

  Wnt signaling plays critical roles in cell fate determination in essentially every tissue in all animals, regulates tissue homeostasis in many adult tissues, and is inappropriately activated in many human cancers. It has been the focus of research for decades, and we have an outline of signal transduction. Remarkably, some of the key questions of Wnt signaling remain controversial. Central among these are questions about the nature of the negative regulatory destruction complex, its mechanism of action and how it is turned down by Wnt signaling. Here Saskia and colleagues take a novel and very exciting approach to these questions, combining innovative quantitative live-cell imaging and computational modelling.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife