1. Bilateral regulation of EGFR activity and local PI dynamics observed with superresolution microscopy

    This article has 5 authors:
    1. Mitsuhiro Abe
    2. Masataka Yanagawa
    3. Michio Hiroshima
    4. Toshihide Kobayashi
    5. Yasushi Sako

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Activation of the mitochondrial unfolded protein response regulates the dynamic formation of stress granules

    This article has 6 authors:
    1. Marta Lopez-Nieto Jordana
    2. Zhaozhi Sun
    3. Rahme Safakli
    4. Alessia Ruggieri
    5. Ioannis Smyrnias
    6. Nicolas Locker

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Katanin, kinesin-13 and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes

    This article has 6 authors:
    1. Elizabeth A Beath
    2. Cynthia Bailey
    3. Meghana Mahantesh Magadum
    4. Shuyan Qiu
    5. Karen L McNally
    6. Francis J McNally
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable paper that identifies a potential challenge for embryos during fertilization: holding sperm contents in the fertilized embryos away from the oocyte meiotic spindle so that they don't get ejected into the polar body during meiotic chromosome segregation. The authors identify proteins involved in cytoplasmic streaming and maintaining the grouping of paternal organelles as being critical for this process. There remain minor weaknesses in the data presented but the paper provides solid evidence for the majority of its claims, and while the findings may pertain to a narrow audience the tools used and basic characterization shown will likely be relied upon by many in the community and therefore is of high value.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Human receptive endometrial organoid for deciphering the implantation window

    This article has 15 authors:
    1. Yu Zhang
    2. Rusong Zhao
    3. Chaoyan Yang
    4. Jinzhu Song
    5. Peishu Liu
    6. Yan Li
    7. Boyang Liu
    8. Tao Li
    9. Changjian Yin
    10. Minghui Lu
    11. Zhenzhen Hou
    12. Chuanxin Zhang
    13. Zi-Jiang Chen
    14. Keliang Wu
    15. Han Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable development of endometrial organoid culture methodology that mimics the window of implantation. Functional validation to demonstrate its robustness is lacking; therefore, the study is considered incomplete. The data may be interesting to embryologists and investigators working on reproductive biology and medicine.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

    This article has 6 authors:
    1. Liyi Wang
    2. Shiqi Liu
    3. Shu Zhang
    4. Yizhen Wang
    5. Yanbing Zhou
    6. Tizhong Shan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The present study provides valuable information into the regulatory mechanisms through which conjugated linoleic acids influence intramuscular fat deposition and muscle fiber transformation in pigs. The data are analyzed comprehensively using solid and validated single nuclei methodology. Overall, the provided data are convincing and support the conclusion of the study.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Mapping the human hematopoietic stem and progenitor cell hierarchy through integrated single-cell proteomics and transcriptomics

    This article has 12 authors:
    1. Benjamin Furtwängler
    2. Nil Üresin
    3. Sabrina Richter
    4. Mikkel Bruhn Schuster
    5. Despoina Barmpouri
    6. Henrietta Holze
    7. Anne Wenzel
    8. Kirsten Grønbæk
    9. Kim Theilgaard-Mönch
    10. Fabian J. Theis
    11. Erwin M. Schoof
    12. Bo T Porse

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  7. Coherent Raman microscopy detects nucleolar defects through amide I peak shifts originating from β-sheets: an application to visualizing ongoing cellular senescence

    This article has 5 authors:
    1. Shigeo Ishibashi
    2. Akihito Inoko
    3. Yuki Oka
    4. Philippe Leproux
    5. Hideaki Kano

    Reviewed by Arcadia Science

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Cell cycle-dependent mRNA localization in P-bodies

    This article has 20 authors:
    1. Adham Safieddine
    2. Marie-Noëlle Benassy
    3. Thomas Bonte
    4. Floric Slimani
    5. Oriane Pourcelot
    6. Michel Kress
    7. Michèle Ernoult-Lange
    8. Maïté Courel
    9. Emeline Coleno
    10. Arthur Imbert
    11. Antoine Laine
    12. Annie Munier Godebert
    13. Angelique Vinit
    14. Corinne Blugeon
    15. Guillaume Chevreux
    16. Daniel Gautheret
    17. Thomas Walter
    18. Edouard Bertrand
    19. Marianne Bénard
    20. Dominique Weil

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans

    This article has 8 authors:
    1. Raquel Romero-Bueno
    2. Adrian Fragoso-Luna
    3. Cristina Ayuso
    4. Nina Mellmann
    5. Alan Kavsek
    6. Christian G. Riedel
    7. Jordan D Ward
    8. Peter Askjaer

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    This article has 24 authors:
    1. Slaven Crnkovic
    2. Helene Thekkekara Puthenparampil
    3. Shirin Mulch
    4. Valentina Biasin
    5. Jochen Wilhelm
    6. Marek Bartkuhn
    7. Ehsan Bonyadi Rad
    8. Alicja Wawrzen
    9. Ingrid Matzer
    10. Ankita Mitra
    11. Ryan Leib
    12. Bence M Nagy
    13. Anita Sahu-Osen
    14. Francesco Valzano
    15. Natalie Bordag
    16. Matthias Evermann
    17. Konrad Hoetzenecker
    18. Andrea Olschewski
    19. Senka Ljubojevic-Holzer
    20. Malgorzata Wygrecka
    21. Kurt Stenmark
    22. Leigh M Marsh
    23. Vinicio de Jesus Perez
    24. Grazyna Kwapiszewska
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study explored a molecular comparison of smooth muscle and neighboring fibroblast cells found in lung blood vessels afflicted by a disease called pulmonary arterial hypertension. In doing so, the authors described distinct disease-associated states of each of these cell types with further insights into the cellular communication and crosstalk between them. The strength of evidence was convincing through the use of complementary and sophisticated tools, accompanied by rare isolation of human diseased lung blood vessel cells that were source-matched to the same donor for direct comparison.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity