Cancer Biology

Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

1. Gökçe Senger
2. Stefano Santaguida
3. Martin H Schaefer

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to the cancer biology community. The study leverages high-throughput genomic and proteomic data to evaluate the role of aneuploidy on functional pathway changes in cancer.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity

1. Chie Sugimoto
2. Yukie Murakami
3. Eisuke Ishii
4. Hiroyoshi Fujita
5. Hiroshi Wakao

• Curated by eLife

  Evaluation Summary:

  This paper describes a reprogramming platform for studying mucosal-associated invariant T (MAIT) cells that can overcome the current technology limitations in studying MAITs. With more detailed elucidation the identity of reprogrammed MAIT cells compared to endogenous MAITs, this paper will of broad interest to those studying the role of these cells in tumor immunity.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Proton export drives the Warburg Effect

1. Shonagh Russell
2. Liping Xu
3. Yoonseok Kam
4. Dominique Abrahams
5. Daniel Verduzco
6. Joseph Johnson
7. Tamir Epstein
8. Epifanio Ruiz
9. Mark C. Lloyd
10. Jonathan Wojtkowiak
11. Alex S. Lopez
12. Marilyn M. Bui
13. Robert J. Gillies
14. Pawel Swietach
15. Bryce Ordway

• Curated by eLife

  Evaluation Summary:

  This manuscript addresses a phenomenon of great interest to researchers in cell metabolism and cancer biology: namely, why do cancer cells often secrete high levels of lactate, despite the presence of abundant oxygen to power nutrient oxidation (Warburg effect). The authors propose that lactate export and subsequent extracellular acidification provides a selective advantage and the concomitant rise in intracellular pH is sufficient to drive flux through glycolysis, thereby sustaining the Warburg effect. This is an intriguing hypothesis that ties together many published observations, but it would require further support both from the technical and conceptual side.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

JAMMIT Analysis Defines 2 Semi-Independent Immune Processes Common to 29 Solid Tumors

1. Emory Zitello
2. Michael Vo
3. Shaoqiu Chen
4. Scott Bowler
5. Vedbar Khadka
6. Thomas Wenska
7. Peter Hoffmann
8. Gordon Okimoto
9. Youping Deng

• Curated by eLife

  Evaluation Summary:

  This study provides a sound and novel algorithm to analyze the massive cancer data and its findings greatly help inform novel cancer immunotherapy across various cancer types. Moreover, a 3-gene signature was established based upon Tc1, Tc17, and immune cold tumors to estimate the abundance of monocytic infiltrates that could potentially impact on the overall survival of cancer patients. It might be of great interest to the general audience of cancer biologists, immunologists and computational biologists.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewer remained anonymous to the authors.)

Reviewed by eLife

Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

1. Anthony Lozano
2. Francois-Régis Souche
3. Carine Chavey
4. Valérie Dardalhon
5. Christel Ramirez
6. Serena Vegna
7. Guillaume Desandre
8. Anaïs Riviere
9. Amal Zine El Aabidine
10. Philippe Fort
11. Leila Akkari
12. Urszula Hibner
13. Damien Grégoire

Reviewed by Review Commons

The extracellular matrix supports cancer cell growth under amino acid starvation by promoting tyrosine catabolism

1. Mona Nazemi
2. Bian Yanes
3. Montserrat Llanses Martinez
4. Heather Walker
5. Frederic Bard
6. Elena Rainero

Reviewed by Review Commons, ASAPbio crowd review

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

1. David J Hosfield
2. Sandra Weber
3. Nan-Sheng Li
4. Madline Sauvage
5. Carstyn F Joiner
6. Govinda R Hancock
7. Emily A Sullivan
8. Estelle Ndukwe
9. Ross Han
10. Sydney Cush
11. Muriel Lainé
12. Sylvie C Mader
13. Geoffrey L Greene
14. Sean W Fanning

• Curated by eLife

  Evaluation Summary:

  This paper will be of broad interest to many fields, including drug discovery, cancer biology, and structure biology. It makes a significant advance in understanding the mechanism of action of hormone therapies for breast cancer, and how resistance driving mutations alter drug responses. The structural biology data has clear potential for strong impact though some additional analysis might be needed.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

1. Maxim I Maron
2. Alyssa D Casill
3. Varun Gupta
4. Jacob S Roth
5. Simone Sidoli
6. Charles C Query
7. Matthew J Gamble
8. David Shechter

• Curated by eLife

  Evaluation Summary:

  This manuscript addresses outstanding questions about the molecular mechanisms by which the two types of arginine-methylating enzymes affect the processing and fate of transcripts in mammalian cells. This work makes important inroads into these questions, uncovering an inverse effect of the two types of enzymes on intron retention during post-transcriptional splicing, linking the effects to specific target proteins. With better support of some key claims , the paper will provide a lot of new information about the functional consequences of asymmetric and symmetric demethylation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

1. Oscar Urtatiz
2. Amanda Haage
3. Guy Tanentzapf
4. Catherine D Van Raamsdonk

• Curated by eLife

  Evaluation Summary:

  In this manuscript, the authors study the discrepancy between the frequency of mutations in Gq alpha subunit (GNAQ and its paralogue GNA11) in uveal vs cutaneous melanoma. They hypothesize that the restriction of GNAQ and GNA11 mutations to non-epithelial melanomas is due to epidermal factors, which convert the impact of GNAQ Q209L mutation from being oncogenic to being inhibitory to melanocyte survival and proliferation, and reduce the maintenance, rather than the establishment of interfollicular epithelial melanocytes. This work provides new insights into the poorly understood difference in mutation frequency in different melanoma types.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

1. Seaho Kim
2. CheukMan C Au
3. Mohd Azrin Bin Jamalruddin
4. Naira Essam Abou-Ghali
5. Eiman Mukhtar
6. Luigi Portella
7. Adeline Berger
8. Daniel Worroll
9. Prerna Vatsa
10. David S Rickman
11. David M Nanus
12. Paraskevi Giannakakou

• Curated by eLife

  Evaluation Summary:

  Truncated splice variants of the androgen receptor (AR) lacking a ligand-binding domain are thought to contribute to therapeutic resistance to antiandrogens in advanced prostate cancer. In this manuscript, the authors show that AR-V7, the most well-studied such truncated variant, displays a different mechanism of nuclear targeting and interaction with chromatin compared to the full-length AR. This work provides new insights into how AR-V7 may contribute to the pathology of Castrate-Resistant Prostate Cancer and will be of interest to researchers trying to improve prostate cancer therapies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife