1. Drug-Induced p53 Activation Limits Pancreatic Cancer Initiation

    This article has 7 authors:
    1. Jennifer J Twardowski
    2. Thomas I Heist
    3. Zamira Guerra Soares
    4. Emily S Berry
    5. Luis I Ruffolo
    6. Christoph Pröschel
    7. Stephano S Mello

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

    This article has 18 authors:
    1. Xin Zhang
    2. Guangyu Zhang
    3. Shuli Sang
    4. Yang Fei
    5. Xiaopeng Cao
    6. Wenge Song
    7. Feide Liu
    8. Jinze Che
    9. Haoxia Tao
    10. Hongwei Wang
    11. Lihua Zhang
    12. Yiyan Guan
    13. Shipeng Rong
    14. Lijuan Pei
    15. Sheng Yao
    16. Yanchun Wang
    17. Min Zhang
    18. Chunjie Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable description of the cellular and transcriptional landscape of the tumor microenvironment in 27 gastric cancer (GC) patients based on their H. pylori status (HpGC, ex-HpGC, non-HpGC). The single-cell RNA sequencing dataset and computational analysis are convincing and provide a starting point that is of value for understanding H pylori-associated GC cell type composition, cell transitions, and mechanisms of response to therapy. The section correlating immunotherapy outcomes with GC cell type compositions from bulk RNAseq would have been strengthened by further comparing H. pylori GC versus non H. pylori GC.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    This article has 10 authors:
    1. Chong Zhang
    2. Zuoyan Zhang
    3. Yueyi Wu
    4. Yuchen Wu
    5. Jing Cheng
    6. Kaizhi Luo
    7. Zhidi Li
    8. Manman Zhang
    9. Jian Wang
    10. Yangling Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable mechanistic insight into NSCLC progression, both in terms of tumour metastasis and the development of chemoresistance. The authors draw upon a range of techniques and assays and the evidence shown is solid and has been strengthened by incorporation of suggestions by the two reviewers. The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  4. Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML

    This article has 5 authors:
    1. Jessica Whittle
    2. Stefan Meyer
    3. Georges Lacaud
    4. Syed Murtuza Baker
    5. Mudassar Iqbal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides a single-cell transcriptomic atlas for AML (222 samples comprising 748,679 cells) integrating data from multiple studies. They use this dataset to investigate t(8;21) AML, and they reconstruct the Gene Regulatory Network and enhancer Gene Regulatory Network, which allowed identification of interesting targets. This aggregation is useful and can help infer differences in genetic regulatory modules based on the age of disease onset, which may help explain age-related variations in prognosis and disease development. However, result interpretations and the motivation and critical analysis of the applied computational methods are incomplete, and the statistical analyses lack control experiments and should be improved to avoid potential selection bias in the later analyses.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer

    This article has 16 authors:
    1. Laura Morano
    2. Nadia Vezzio-Vié
    3. Adam Aissanou
    4. Tom Egger
    5. Antoine Aze
    6. Solène Fiachetti
    7. Benoît Bordignon
    8. Cédric Hassen-Khodja
    9. Hervé Seitz
    10. Louis-Antoine Milazzo
    11. Véronique Garambois
    12. Laurent Chaloin
    13. Nathalie Bonnefoy
    14. Céline Gongora
    15. Angelos Constantinou
    16. Jihane Basbous
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study demonstrates that the GSK-3 inhibitor AZD2858 inhibits the formation of TOPBP1 condensates and hence DNA damage responses in colorectal cancer cells. The evidence supporting the claims of the authors is convincing, although uncovering how this drug blocks bio-condensate formation would have strengthened the study. The work will be of interest to cancer researchers searching for synergistic drug combination strategies.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

    This article has 11 authors:
    1. Yu-Chia Chen
    2. Mamoru Takada
    3. Aerica Nagornyuk
    4. Muhan Yu
    5. Hideyuki Yamada
    6. Takeshi Nagashima
    7. Masayuki Ohtsuka
    8. Jennifer G DeLuca
    9. Steven M Markus
    10. Motoki Takaku
    11. Aussie Suzuki
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable findings that MK2 inhibitor CMPD1 can inhibit the growth, migration and invasion of breast cancer cells both in vitro and in vivo. The evidence supporting the claims of the authors is solid, although the detailed molecular mechanism and additional animal experiments would strengthen the paper. This study will be of interest to the breast cancer field.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

    This article has 7 authors:
    1. Xuantong Gong
    2. Lishuang Gu
    3. Di Yang
    4. Yu He
    5. Qian Li
    6. Hao Qin
    7. Yong Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a useful finding for the ferroptosis-mediated tumor microenvironment (TME) in triple-negative breast cancer (TNBC) using public single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing data. The data were collected and analyzed using solid and validated methodology and can be used as a starting point for functional studies of TME in TNBC. The work will be of interest to medical biologists working in the field of TNBC.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  8. Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

    This article has 27 authors:
    1. David Papadopoli
    2. Ranveer Palia
    3. Predrag Jovanovic
    4. Sébastien Tabariès
    5. Emma Ciccolini
    6. Valerie Sabourin
    7. Sebastian Igelmann
    8. Shannon McLaughlan
    9. Lesley Zhan
    10. HaEun Kim
    11. Nabila Chekkal
    12. Krzysztof J Szkop
    13. Thierry Bertomeu
    14. Jibin Zeng
    15. Julia Vassalakis
    16. Farzaneh Afzali
    17. Slim Mzoughi
    18. Ernesto Guccione
    19. Mike Tyers
    20. Daina Avizonis
    21. Ola Larsson
    22. Lynne-Marie Postovit
    23. Sergej Djuranovic
    24. Josie Ursini-Siegel
    25. Peter M Siegel
    26. Michael Pollak
    27. Ivan Topisirovic
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating that ETFDH suppression results in accumulation of amino acids that impact metabolism via hyperactive mTORC1.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

    This article has 3 authors:
    1. Mei Ling Leong
    2. Christiane Ruedl
    3. Klaus Karjalainen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further mechanistic analyses. These data will be interesting to cancer biologists, especially those trying to understand late-stage complications such as cachexia and wasting, a major cause of cancer morbidity and mortality.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Human RAP2A Homolog of the Drosophila Asymmetric Cell Division Regulator Rap2l Targets the Stemness of Glioblastoma Stem Cells

    This article has 5 authors:
    1. Maribel Franco
    2. Ricardo Gargini
    3. Víctor M Barberá
    4. Miguel Saceda
    5. Ana Carmena
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study explores the role of RAP2A in asymmetric cell division (ACD) regulation in glioblastoma stem cells (GSCs), drawing parallels to Drosophila ACD mechanisms and proposing that an imbalance toward symmetric divisions drives tumor progression. While findings on RAP2A's role in GSC expansion are promising, the study is nevertheless incomplete. Limitations include the lack of comprehensive GBM subtype analysis, insufficient mechanistic validation, and reliance on neurosphere models without in vivo confirmation. Addressing those gaps is necessary to substantiate the study's claims.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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