Biophysics

The genotype‐phenotype landscape of an allosteric protein

1. Drew S Tack
2. Peter D Tonner
3. Abe Pressman
4. Nathan D Olson
5. Sasha F Levy
6. Eugenia F Romantseva
7. Nina Alperovich
8. Olga Vasilyeva
9. David Ross

Reviewed by Review Commons

Structural characterization of the ANTAR antiterminator domain bound to RNA

1. James L Walshe
2. Rezwan Siddiquee
3. Karishma Patel
4. Sandro F Ataide

• Curated by eLife

  Summary: The reviewers were excited by the structural data, and felt that the structure represents an important advance in our understanding of ANTAR domain proteins. Nonetheless, while the reviewers found the proposed model of ANTAR regulation to be interesting, they raised concerns about the limited evidence in support of this model. In addition to the suggestions in the individual reviews, the authors thought the model could be tested using mutagenesis together with an in vivo or in vitro reporter system, and/or by structural studies of nascent transcripts in transcription complexes with EutV.

Reviewed by eLife

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

1. Amanda Jack
2. Luke S. Ferro
3. Michael J. Trnka
4. Eddie Wehri
5. Amrut Nadgir
6. Xammy Huu Wrynla
7. Douglas Fox
8. Katelyn Costa
9. Sarah Stanley
10. Julia Schaletzky
11. Ahmet Yildiz

Reviewed by eLife, ScreenIT

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

1. Achinta Sannigrahi
2. Sourav Chowdhury
3. Bidisha Das
4. Amrita Banerjee
5. Animesh Halder
6. Amaresh Kumar
7. Mohammed Saleem
8. Athi N Naganathan
9. Sanat Karmakar
10. Krishnananda Chattopadhyay

Reviewed by eLife

Characterization of the dynamic resting state of a pentameric ligand-gated ion channel by cryo-electron microscopy and simulations

1. U Rovšnik
2. Y Zhuang
3. L Axelsson
4. BO Forsberg
5. V Lim
6. M Carroni
7. C Blau
8. RJ Howard
9. E Lindahl

Reviewed by eLife

Calponin-homology domain mediated bending of membrane-associated actin filaments

1. Saravanan Palani
2. Sayantika Ghosh
3. Esther Ivorra-Molla
4. Scott Clarke
5. Andrejus Suchenko
6. Mohan K Balasubramanian
7. Darius Vasco Köster

Reviewed by eLife

Through-grid wicking enables high-speed cryoEM specimen preparation

1. Yong Zi Tan
2. John L. Rubinstein

Reviewed by eLife

Proofreading through spatial gradients

1. Vahe Galstyan
2. Kabir Husain
3. Fangzhou Xiao
4. Arvind Murugan
5. Rob Phillips

Reviewed by eLife

Structures of an intact yeast V-ATPase alone and in complex with bacterial effector VopQ

1. Wei Peng
2. Jessie Fernandez
3. Amanda K. Casey
4. Lisa N. Kinch
5. Diana R. Tomchick
6. Kim Orth

Reviewed by eLife

Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

1. Marija Liutkute
2. Manisankar Maiti
3. Ekaterina Samatova
4. Jörg Enderlein
5. Marina V Rodnina

Reviewed by eLife