Biophysics

Transport kinetics across interfaces between coexisting liquid phases

1. Lars Hubatsch
2. Stefano Bo
3. Tyler S Harmon
4. Anthony A Hyman
5. Christoph A Weber
6. Frank Jülicher

• Curated by eLife

  eLife Assessment

  This study offers a valuable theoretical framework for quantifying molecular transport across interfaces between coexisting liquid phases, emphasizing interfacial resistance as a central factor governing transport kinetics. The mathematical derivations are solid. To enhance the paper's relevance and broaden its appeal, it would be helpful to clarify how the key equations connect to existing literature and to elucidate the physical mechanisms underlying scenarios that give rise to substantial interfacial resistance.

Reviewed by eLife

Salmonids elicit an acute behavioral response to heterothermal environments

1. Robert Naudascher
2. Stefano Brizzolara
3. Jonasz Slomka
4. Robert M Boes
5. Markus Holzner
6. Luiz GM Silva
7. Roman Stocker

• Curated by eLife

  eLife Assessment

  This valuable paper investigates how fish avoid thermal disturbances that occur on fast timescales. The authors use a creative experimental approach that quickly creates a vertical thermal interface, which they combine with careful behavioral analyses. The evidence supporting their results is solid, but there is a potential confounding factor between temperature and vertical positioning, and characterization of the thermal interface would greatly assist in interpreting the results.

Reviewed by eLife

PARP1 inhibitors regulate PARP1 structure independent of DNA, reducing binding affinity for single strand breaks

1. Mark Pailing
2. Lotte van Beek
3. Taiana Maia de Oliveira
4. Maria M. Flocco
5. Bart W. Hoogenboom

Reviewed by Arcadia Science

Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

1. Gautham Ganesh
2. Jean-Bernard Fiche
3. Marcelo Nöllmann
4. Julien Mozziconacci

• Curated by eLife

  eLife Assessment

  This manuscript uses modeling approaches to provide mechanistic insight into the structural and dynamic properties of enhancer-promoter interactions in Drosophila. Given the interest in this field, this is a timely approach, and the results give useful insights by providing predictions about the processivity of cohesin loop extrusion in Drosophila and concluding that the compartmental interaction strength is poised near criticality in the coil-globule phase space. The evidence provided to support some of the conclusions is, however, incomplete and would be strengthened by better considering some of the caveats in the data used to constrain the models, such as the use of "homie" genetic elements in the dynamic data. There is insufficient evidence provided for the dynamics being criticality-driven, and in addition, consideration of alternative models would further strengthen the conclusions of the manuscript.

Reviewed by eLife

AF2χ: Predicting protein side-chain rotamer distributions with AlphaFold2

1. Matteo Cagiada
2. F. Emil Thomasen
3. Sergey Ovchinnikov
4. Charlotte M. Deane
5. Kresten Lindorff-Larsen

Reviewed by PREreview