Biophysics

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

1. Lorena Zuzic
2. Firdaus Samsudin
3. Aishwary T. Shivgan
4. Palur V. Raghuvamsi
5. Jan K. Marzinek
6. Alister Boags
7. Conrado Pedebos
8. Nikhil K. Tulsian
9. Jim Warwicker
10. Paul MacAry
11. Max Crispin
12. Syma Khalid
13. Ganesh S. Anand
14. Peter J. Bond

Reviewed by ScreenIT

The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M ^pro )

1. Ali Ebrahim
2. Blake T. Riley
3. Desigan Kumaran
4. Babak Andi
5. Martin R. Fuchs
6. Sean McSweeney
7. Daniel A. Keedy

Reviewed by ScreenIT

Binding of SARS-CoV-2 fusion peptide to host membranes

1. Stefan L. Schaefer
2. Hendrik Jung
3. Gerhard Hummer

Reviewed by ScreenIT

Solubility product constant directs the formation of biomolecular condensates

1. Aniruddha Chattaraj
2. Michael L. Blinov
3. Leslie M. Loew

• Curated by eLife

  Evaluation Summary:

  Recent experiments have raised questions regarding concentration buffering provided by the formation of multicomponent biomolecular condensates via phase separation driven by heterotypic interactions. In this work, Chattaraja et al., demonstrate that the concept of a solubility product, used to describe the solubility limits of ionic solutions, sets an upper limit on concentration thresholds, even in systems where the driving forces for phase separation are primarily heterotypic in nature. Their work suggests that the concept of a solubility product rescues the concept of buffering via phase separation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Python-Microscope – a new open-source Python library for the control of microscopes

1. David Miguel Susano Pinto
2. Mick A. Phillips
3. Nicholas Hall
4. Julio Mateos-Langerak
5. Danail Stoychev
6. Tiago Susano Pinto
7. Martin J. Booth
8. Ilan Davis
9. Ian M. Dobbie

Reviewed by Review Commons

Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide

1. George Khelashvili
2. Ambrose Plante
3. Milka Doktorova
4. Harel Weinstein

Reviewed by ScreenIT

Exploring dynamics and network analysis of spike glycoprotein of SARS-COV-2

1. Mahdi Ghorbani
2. Bernard R. Brooks
3. Jeffery B. Klauda

Reviewed by ScreenIT

Binding mode of SARS-CoV-2 fusion peptide to human cellular membrane

1. Defne Gorgun
2. Muyun Lihan
3. Karan Kapoor
4. Emad Tajkhorshid

Reviewed by ScreenIT

Distant residues modulate conformational opening in SARS-CoV-2 spike protein

1. Dhiman Ray
2. Ly Le
3. Ioan Andricioaei

Reviewed by ScreenIT

The flexibility of ACE2 in the context of SARS-CoV-2 infection

1. Emilia P. Barros
2. Lorenzo Casalino
3. Zied Gaieb
4. Abigail C. Dommer
5. Yuzhang Wang
6. Lucy Fallon
7. Lauren Raguette
8. Kellon Belfon
9. Carlos Simmerling
10. Rommie E. Amaro

Reviewed by ScreenIT