Biophysics

Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

1. Bret A Unger
2. Chun Ying Wu
3. Alexander A Choi
4. Changdong He
5. Ke Xu

• Curated by eLife

  eLife assessment

  This valuable study provides new insight into the disassembly of vimentin filaments and the dependence of this mechanism on net charge, albeit with incomplete evidence. In particular, the experimental replicates are limited (in most cases n=1), there is a lack of quantitative analysis to substantiate claims, inconsistency of the proposed mechanisms with previously published work, and lack of biochemical evidence supporting the observations in cells. Addressing these concerns would strengthen the manuscript and help support the proposed hypothesis on vimentin disassembly.

Reviewed by eLife

Unveiling Cas8 Dynamics and Regulation within a transposon-encoded Cascade-TniQ Complex

1. Amun C. Patel
2. Souvik Sinha
3. Pablo R. Arantes
4. Giulia Palermo

Reviewed by PREreview

Dynamics and activation of membrane-bound B cell receptor assembly

1. Hung N. Do
2. Mingfei Zhao
3. S. Munir Alam
4. S. Gnanakaran

Reviewed by PREreview

The actin cortex acts as a mechanical memory of morphology in confined migrating cells

1. Yohalie Kalukula
2. Marine Luciano
3. Gleb Simanov
4. Guillaume Charras
5. David B. Brückner
6. Sylvain Gabriele

Reviewed by preLights