Biophysics

HIV integrase compacts viral DNA into biphasic condensates

1. Pauline J Kolbeck
2. Marjolein de Jager
3. Margherita Gallano
4. Tine Brouns
5. Ben Bekaert
6. Wout Frederickx
7. Sebastian F Konrad
8. Siska Van Belle
9. Frauke Christ
10. Steven De Feyter
11. Zeger Debyser
12. Laura Filion
13. Jan Lipfert
14. Willem Vanderlinden

• Curated by eLife

  eLife Assessment

  The manuscript by Kolbeck and co-workers is an important contribution to understanding the physical mechanism that controls a key step in the retroviral infectious cycle. The authors employ a wide range of experimental techniques, complemented with Montecarlo simulations, that result in convincing evidence of compaction of HIV DNA by the viral integrase. This manuscript would benefit from in-depth discussion and analysis of the biophysical implications of the results.

Reviewed by eLife

Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity

1. Keisuke Motone
2. Daphne Kontogiorgos-Heintz
3. Jasmine Wee
4. Kyoko Kurihara
5. Sangbeom Yang
6. Gwendolin Roote
7. Yishu Fang
8. Nicolas Cardozo
9. Jeff Nivala

Reviewed by preLights

Exploring breast cancer-related biochemical changes in circulating extracellular vesicles using Raman spectroscopy

1. Arianna Bonizzi
2. Lorena Signati
3. Maria Grimaldi
4. Marta Truffi
5. Francesca Piccotti
6. Stella Gagliardi
7. Giulia Dotti
8. Serena Mazzucchelli
9. Sara Albasini
10. Roberta Cazzola
11. Debanjan Bhowmik
12. Chandrabhas Narayana
13. Fabio Corsi
14. Carlo Morasso

Reviewed by Arcadia Science