Bioinformatics

Federated Knowledge Retrieval Elevates Large Language Model Performance on Biomedical Benchmarks

1. Janet Joy
2. Andrew I. Su

Reviewed by GigaScience

SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets

1. Souvik Seal
2. Brian Neelon

Reviewed by GigaScience

nf-core/proteinfamilies: A scalable pipeline for the generation of protein families

1. Evangelos Karatzas
2. Martin Beracochea
3. Fotis A. Baltoumas
4. Eleni Aplakidou
5. Lorna Richardson
6. James A. Fellows Yates
7. Daniel Lundin
8. nf-core community
9. Aydin Buluç
10. Nikos C. Kyrpides
11. Ilias Georgakopoulos-Soares
12. Georgios A. Pavlopoulos
13. Robert D. Finn

Reviewed by GigaScience

The Hok bacterial toxin: diversity, toxicity, distribution and genomic localization

1. Andrés Escalera-Maurer
2. Adriana Messineo
3. Thibaud T. Renault
4. Elena Nicollin
5. Erika Castaneda-Sastre
6. Matthieu Brunot
7. Cléo Berrehail
8. Anaïs Le Rhun

Reviewed by Review Commons

Interpreting the Effects of DNA Polymerase Variants at the Structural Level Using MAVISp and Molecular Dynamics Simulations

1. Matteo Arnaudi
2. Karolina Krzesińska
3. Ludovica Beltrame
4. Pablo Sánchez-Izquierdo Besora
5. Matteo Tiberti
6. Mef Nilbert
7. Anna Rohlin
8. Elena Papaleo

Reviewed by Review Commons

A genotype-phenotype transformer to assess and explain polygenic risk

1. Ingoo Lee
2. Zachary S. Wallace
3. Yuqi Wang
4. Sungjoon Park
5. Hojung Nam
6. Amit R. Majithia
7. Trey Ideker

Reviewed by Review Commons

Comparative evaluation of computational methods for reconstruction of human viral genomes

1. Maria J. P. Sousa
2. Mari Toppinen
3. Lari Pyöriä
4. Klaus Hedman
5. Antti Sajantila
6. Maria F. Perdomo
7. Diogo Pratas

Reviewed by GigaScience

An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery

1. Wei Zhang
2. Hanchen Huang
3. Lily Wang
4. Brian D. Lehmann
5. Steven X. Chen

Reviewed by GigaScience

Investigating the native functions of [NiFe]-carbon monoxide dehydrogenases through genomic context analysis

1. Maximilian Böhm
2. Henrik Land

• Curated by eLife

  eLife Assessment

  This study presents a valuable analysis of a large dataset of [NiFe]-CODHs, integrating genomic context, operon organization, and clade-specific gene neighborhoods to discern patterns of functional diversification and adaptation. Carefully looking at the CODH genomic context, e.g., CODH-HCP co-occurrence, the authors gain insight into enzymatic activity, biotechnological potential, and differential functional roles. The approach aligns with current standards in genomic enzymology to characterize newly identified enzymes. With solid support, this work provides a broadly informative contribution to the field.

Reviewed by eLife

Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

1. William JF Rieger
2. Mikael Boden
3. Frances Arnold
4. Ariane Mora

• Curated by eLife

  eLife Assessment

  This important contribution to enzyme annotation offers a deep learning framework for catalytic site prediction. Integrating biochemical knowledge with large language models, the authors demonstrate how to extract meaningful information from sequence alone. They introduce Squidly, a freely available new ML modeling framework, that outperforms existing tools on standard benchmarks, including the CataloDB dataset. The evidence is convincing, with an extensively and carefully addressed narrative upon revision.

Reviewed by eLife