Bioinformatics

Blood transcriptomics analysis offers insights into variant-specific immune response to SARS-CoV-2

1. Markus Hoffmann
2. Lina-Liv Willruth
3. Alexander Dietrich
4. Hye Kyung Lee
5. Ludwig Knabl
6. Nico Trummer
7. Jan Baumbach
8. Priscilla A. Furth
9. Lothar Hennighausen
10. Markus List

Reviewed by Rapid Reviews Infectious Diseases

MAVISp: A Modular Structure-Based Framework for Protein Variant Effects

1. Matteo Arnaudi
2. Mattia Utichi
3. Kristine Degn
4. Ludovica Beltrame
5. Simone Scrima
6. Karolina Krzesińska
7. Pablo Sánchez-Izquierdo Besora
8. Katrine Meldgård
9. Laura Bauer
10. Terézia Dorčaková
11. Anna Melidi
12. Lorenzo Favaro
13. Eleni Kiachaki
14. Anu Oswal
15. Alberte Heering Estad
16. Joachim Breitenstein
17. Jordan Safer
18. Paraskevi Saridaki
19. Francesca Maselli
20. Burcu Aykac Fas
21. Guglielmo Tedeschi
22. Philipp Becker
23. Jérémy Vinhas
24. Alberto Pettenella
25. Peter Wad Sackett
26. Claudia Cava
27. Anna Rohlin
28. Mef Nilbert
29. Sumaiya Iqbal
30. Matteo Lambrughi
31. Matteo Tiberti
32. Elena Papaleo

Reviewed by Review Commons

Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels

1. Rahil Taujale
2. Sung Jin Park
3. Nathan Gravel
4. Saber Soleymani
5. Rayna Carter
6. Kennady Boyd
7. Sarah Keuning
8. Zheng Ruan
9. Wei Lü
10. Natarajan Kannan

• Curated by eLife

  eLife Assessment

  In this manuscript Taujale et al describe an interdisciplinary approach to mine the human channelome and further discover orthologues across diverse organisms. Further, this work provides evidence that supports a role for conserved residues in CALHM channel gating. Overall this important work presents findings that can be helpful to the ion channel community, as well as to those interested in improved methods for mining sequence space for their protein of interest. However, further validation of the improvements their approach shows over previous approaches is needed, making this a solid contribution to the literature in this field.

Reviewed by eLife

ParTIpy: A Scalable Framework for Archetypal Analysis and Pareto Task Inference

1. Philipp S. L. Schäfer
2. Leoni Zimmermann
3. Paul L. Burmedi
4. Avia Walfisch
5. Noa Goldenberg
6. Shira Yonassi
7. Einat Shaer Tamar
8. Miri Adler
9. Jovan Tanevski
10. Ricardo O. Ramirez Flores
11. Julio Saez-Rodriguez

Reviewed by Review Commons

Human single-cell atlas analysis reveals heterogeneous endothelial signaling

1. Zimo Zhu
2. Rongbin Zheng
3. Yang Yu
4. Lili Zhang
5. Kaifu Chen

Reviewed by preLights

Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

1. Guangzhao Cheng
2. Aki Vehtari
3. Lu Cheng

• Curated by eLife

  eLife Assessment

  This study presents SegPore, a valuable new method for processing direct RNA nanopore sequencing data, which improves the segmentation of raw signals into individual bases and boosts the accuracy of modified base detection. The evidence presented to benchmark SegPore is solid, and the authors provide a fully documented implementation of the method. SegPore will be of particular interest to researchers studying RNA modifications.

Reviewed by eLife

MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

1. Benjamin Gallean
2. Tao Laurent
3. Kilian Biasuz
4. Ange Clement
5. Noura Faraj
6. Patrick Lemaire
7. Emmanuel Faure

• Curated by eLife

  eLife Assessment

  This important work presents technical and conceptual advances with the release of MorphoNet 2.0, a versatile and accessible platform for 3D+T segmentation and analysis. The authors provide compelling evidence across diverse datasets, and the clarity of the manuscript together with the software's usability broadens its impact. Although the strength of some improvements is hard to fully gauge given sample complexity, the tool is a significant step forward that will likely impact many biological imaging fields.

Reviewed by eLife

EssSubgraph improves performance and generalizability of mammalian essential gene prediction with large networks

1. Haimei Wen
2. Susan Carpenter
3. Karen McGinnis
4. Andrew Nelson
5. Keriayn Smith
6. Tian Hong

Reviewed by GigaScience

GFFx: A Rust-based suite of utilities for ultra-fast genomic feature extraction

1. Baohua Chen
2. Dongya Wu
3. Guojie Zhang

Reviewed by GigaScience

Improving the Reliability and Quality of Nextflow Pipelines with nf-test

1. Lukas Forer
2. Sebastian Schoenherr

Reviewed by GigaScience