Bioengineering

Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

1. Vikas Chonira
2. Young Do Kwon
3. Jason Gorman
4. James Brett Case
5. Zhiqiang Ku
6. Rudo Simeon
7. Ryan G. Casner
8. Darcy R. Harris
9. Adam S. Olia
10. Tyler Stephens
11. Lawrence Shapiro
12. Hannah Boyd
13. Yaroslav Tsybovsky
14. Florian Krammer
15. Michael S. Diamond
16. Peter D. Kwong
17. Zhiqiang An
18. Zhilei Chen

Reviewed by ScreenIT

Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot

1. Catherine M. Kasse
2. Anthony C. Yu
3. Abigail E. Powell
4. Gillie A. Roth
5. Celine S. Liong
6. Carolyn K. Jons
7. Awua Buahin
8. Caitlin L. Maikawa
9. Xueting Zhou
10. Sawsan Youssef
11. Jacob E. Glanville
12. Eric A. Appel

Reviewed by ScreenIT

Adaptation‐Proof SARS‐CoV‐2 Vaccine Design

1. Yashavantha L. Vishweshwaraiah
2. Brianna Hnath
3. Brendan Rackley
4. Jian Wang
5. Abhinay Gontu
6. Morgan Chandler
7. Kirill A. Afonin
8. Suresh V. Kuchipudi
9. Neil Christensen
10. Neela H. Yennawar
11. Nikolay V. Dokholyan

Reviewed by ScreenIT

Net-Shaped DNA Nanostructures Designed for Rapid/Sensitive Detection and Potential Inhibition of the SARS-CoV-2 Virus

1. Neha Chauhan
2. Yanyu Xiong
3. Shaokang Ren
4. Abhisek Dwivedy
5. Nicholas Magazine
6. Lifeng Zhou
7. Xiaohe Jin
8. Tianyi Zhang
9. Brian T. Cunningham
10. Sherwood Yao
11. Weishan Huang
12. Xing Wang

Reviewed by ScreenIT

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds

1. Quinton Smith
2. Jennifer Bays
3. Linqing Li
4. Haniyah Shareef
5. Christopher S. Chen
6. Sangeeta N. Bhatia

• Curated by eLife

  Evaluation Summary:

  This paper is of interest for cell biologists, developmental biologists and tissue engineers. The authors identify a combination of natural extracellular matrix and growth factors that enables to grow cholangiocytes as branched three-dimensional ducts in culture. The work is physiologically relevant and represents an interesting step forward in the study of bile duct formation and disease, although the cultured ducts could be characterized more in depth.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Argon plasma-modified bacterial cellulose filters for protection against respiratory pathogens

1. Anna Żywicka
2. Daria Ciecholewska-Juśko
3. Magdalena Charęza
4. Radosław Drozd
5. Peter Sobolewski
6. Adam Junka
7. Selestina Gorgieva
8. Miroslawa El Fray
9. Karol Fijałkowski

Reviewed by ScreenIT

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning

1. Nuno GB Neto
2. Sinead A O'Rourke
3. Mimi Zhang
4. Hannah K Fitzgerald
5. Aisling Dunne
6. Michael G Monaghan

• Curated by eLife

  Evaluation Summary:

  Neto et al set out to use Two-Photon FLIM and machine learning to classify macrophages that are polarised along the M1/M2 axis and then subjected to different metabolic stresses classically used to distinguish metabolic strategies of different cell states. Additional information is sought regarding the photophysics of the measurements and if there are an adequate number of photons to fairly compare the three conditions. The work will be of interest to immunologists, physiologists interested in metabolism and engineers looking to translate the findings.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

1. Matias I Autio
2. Efthymios Motakis
3. Arnaud Perrin
4. Talal Bin Amin
5. Zenia Tiang
6. Dang Vinh Do
7. Jiaxu Wang
8. Joanna Tan
9. Shirley Suet Lee Ding
10. Wei Xuan Tan
11. Chang Jie Mick Lee
12. Adrian Kee Keong Teo
13. Roger SY Foo

Reviewed by Review Commons

Vascular inflammation exposes perivascular cells to SARS-CoV-2 infection

1. Cristiane Miranda Franca
2. Amin Mansoorifar
3. Avathamsa Athirasala
4. Ramesh Subbiah
5. Anthony Tahayeri
6. Luiz Bertassoni

Reviewed by ScreenIT

Genetically Engineered MRI-Trackable Extracellular Vesicles as SARS-CoV-2 Mimetics for Mapping ACE2 Binding In Vivo

1. Andrea Galisova
2. Jiri Zahradnik
3. Hyla Allouche-Arnon
4. Mattia I. Morandi
5. Paula Abou Karam
6. Michal Fisler
7. Ori Avinoam
8. Neta Regev-Rudzki
9. Gideon Schreiber
10. Amnon Bar-Shir

Reviewed by ScreenIT