Bioengineering

Bacterial Wastewater-Based Epidemiology Using Surface-Enhanced Raman Spectroscopy and Machine Learning

1. Liam K. Herndon
2. Yirui Zhang
3. Fareeha Safir
4. Babatunde Ogunlade
5. Halleh B. Balch
6. Alexandria B. Boehm
7. Jennifer A. Dionne

Reviewed by Arcadia Science

Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection

1. Shilin Zhong
2. Ruiyu Wang
3. Xinwei Gao
4. Qingchun Guo
5. Rui Lin
6. Minmin Luo

• Curated by eLife

  eLife Assessment

  This study presents an important practical modification of the orthogonal hybridization chain reaction (HCR) technique, a promising yet underutilized method with broad potential for future applications across various fields. The authors advance this technique by integrating peptide ligation technology and nanobody-based antibody mimetics - cost-effective and scalable alternatives to conventional antibodies - into a DNA-immunoassay framework, which convincingly merges oligonucleotide-based detection with immunoassay methodologies.

Reviewed by eLife

Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

1. M Reza Bahrani Fard
2. Jessica Chan
3. A Thomas Read
4. Guorong Li
5. Lin Cheng
6. Babak N Safa
7. Seyed Mohammad Siadat
8. Anamik Jhunjhunwala
9. Hans E Grossniklaus
10. Stanislav Y Emelianov
11. W Daniel Stamer
12. Markus H Kuehn
13. C Ross Ethier

• Curated by eLife

  eLife Assessment

  This study has fundamental findings that support the potential application of exogenous stem cell therapy as a viable therapeutic option for the management of intraocular pressure (IOP) and to increase outflow facility. The evidence supporting the clinical application of stem cells is compelling, using a combination of established in vivo and ex vivo experimental techniques. The work will be of interest to both basic stem cell biologists and clinical glaucoma specialists.

Reviewed by eLife

AI.zymes – A modular platform for evolutionary enzyme design

1. Lucas Primus Merlicek
2. Jannik Neumann
3. Abbie Lear
4. Vivian Degiorgi
5. Moor de Waal
6. Tudor-Stefan Cotet
7. Adrian J. Mulholland
8. Hans Adrian Bunzel

Reviewed by Arcadia Science

Antibody affinity engineering using antibody repertoire data and machine learning

1. Lena Erlach
2. Simon Friedensohn
3. Daniel Neumeier
4. Derek M. Mason
5. Sai T. Reddy

Reviewed by Arcadia Science

3D mechanical confinement directs muscle stem cell fate and function

1. GaYoung Park
2. Josh A. Grey
3. Foteini Mourkioti
4. Woojin M. Han

Reviewed by preLights

Heart Scar-In-A-Dish: Tissue Culture Platform to Study Myocardial Infarct Healing In Vitro

1. MJ Potter
2. JD Heywood
3. SJ Coeyman
4. WJ Richardson

Reviewed by preLights

Toward De Novo Protein Design from Natural Language

1. Fengyuan Dai
2. Shiyang You
3. Chentong Wang
4. Yuliang Fan
5. Jin Su
6. Chenchen Han
7. Xibin Zhou
8. Jianming Liu
9. Hui Qian
10. Shunzhi Wang
11. Anping Zeng
12. Yajie Wang
13. Hongyuan Lu
14. Fajie Yuan

Reviewed by Arcadia Science

Self-Organizing Neural Networks in Novel Moving Bodies: Anatomical, Behavioral, and Transcriptional Characterization of a Living Construct with a Nervous System

1. Haleh Fotowat
2. Laurie O’Neill
3. Léo Pio-Lopez
4. Megan Sperry
5. Patrick Erickson
6. Tiffany Lin
7. Michael Levin

Reviewed by Arcadia Science

Free-Form Microfluidic Microneedle Array Patches

1. Ian A. Coates
2. Madison M. Driskill
3. Netra U. Rajesh
4. Gabriel Lipkowitz
5. Dan Ilyin
6. Yue Xu
7. Maria T. Dulay
8. Gunilla B. Jacobson
9. Jillian L. Perry
10. Shaomin Tian
11. Joseph M. DeSimone

Reviewed by Arcadia Science