Biochemistry

High-Potency Polypeptide-based Inhibition of Enveloped-virus Glycoproteins

1. Jianpeng Ma
2. Adam Campos Acevedo
3. Qinghua Wang

Reviewed by ScreenIT

Human Basigin (CD147) Does Not Directly Interact with SARS-CoV-2 Spike Glycoprotein

1. Robert J. Ragotte
2. David Pulido
3. Francesca R. Donnellan
4. Michelle L. Hill
5. Giacomo Gorini
6. Hannah Davies
7. Juliane Brun
8. Kirsty McHugh
9. Lloyd D. W. King
10. Katherine Skinner
11. Kazutoyo Miura
12. Carole A. Long
13. Nicole Zitzmann
14. Simon J. Draper

Reviewed by ScreenIT

An Innovative antibody-based Plug-and-Play strategy for SARS-CoV-2

1. Gururaj Shivange
2. Debananda Gogoi
3. Jogender Tushir-Singh

Reviewed by ScreenIT

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

1. Xiaomin Ni
2. Martin Schröder
3. Vincent Olieric
4. May E. Sharpe
5. Victor Hernandez-Olmos
6. Ewgenij Proschak
7. Daniel Merk
8. Stefan Knapp
9. Apirat Chaikuad

Reviewed by ScreenIT

Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies

1. Gabriele Cerutti
2. Micah Rapp
3. Yicheng Guo
4. Fabiana Bahna
5. Jude Bimela
6. Eswar R. Reddem
7. Jian Yu
8. Pengfei Wang
9. Lihong Liu
10. Yaoxing Huang
11. David D. Ho
12. Peter D. Kwong
13. Zizhang Sheng
14. Lawrence Shapiro

Reviewed by ScreenIT

Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants

1. Charlie Laffeber
2. Kelly de Koning
3. Roland Kanaar
4. Joyce H.G. Lebbink

Reviewed by ScreenIT

Proteomic analysis identifies novel binding partners of BAP1

1. Roy Baas
2. Fenna J. van der Wal
3. Onno B. Bleijerveld
4. Haico van Attikum
5. Titia K. Sixma

Reviewed by Review Commons

Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition

1. Fatima Alghoul
2. Schaeffer Laure
3. Gilbert Eriani
4. Franck Martin

• Curated by eLife

  Evaluation Summary:

  Non-canonical pathways for regulating protein synthesis in animals serve important roles for controlling gene expression in critical developmental pathways. Homeobox (Hox) genes encode many mRNAs regulated at the level of translation. A general feature for many of these mRNAs has been the proposal they are regulated by Internal Ribosome Entry Sites and possess sequences in the 5'-untranslated regions of the mRNA that prevent canonical cap-dependent translation, termed "translation inhibitory elements". Here, the authors focus on two Hox mRNAs and find they use entirely different means to achieve the same end of repressing cap-dependent translation. Overall, the experiments support the major conclusions drawn by the authors, and nail down mechanisms that have been left unresolved since the Hox mRNAs were first discovered to be regulated at the level of translation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Spc1 regulates substrate selection for signal peptidase

1. Chewon Yim
2. Yeonji Chung
3. Jeesoo Kim
4. IngMarie Nilsson
5. Jong-Seo Kim
6. Hyun Kim

• Curated by eLife

  Evaluation Summary:

  This interesting and well-executed work addresses the function of one of the subunits of the signal peptidase, a complex that processes signal peptides in a wide variety of secretory and membrane proteins. This topic is of relevance to the membrane cell biology community, and the study will be of broader interest when the authors demonstrate the relevance of their findings to the natural substrates of the studied enzyme.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila

1. Andrea Lukacs
2. Andreas W. Thomae
3. Peter Krueger
4. Tamas Schauer
5. Anuroop V. Venkatasubramani
6. Natalia Y. Kochanova
7. Wasim Aftab
8. Rupam Choudhury
9. Ignasi Forne
10. Axel Imhof

Reviewed by Review Commons