Biochemistry

  1. Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    1. Qi Yang
    2. Thomas A Hughes
    3. Anju Kelkar
    4. Xinheng Yu
    5. Kai Cheng
    6. Sheldon Park
    7. Wei-Chiao Huang
    8. Jonathan F Lovell
    9. Sriram Neelamegham

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation

    1. Tzu-Jing Yang
    2. Pei-Yu Yu
    3. Yuan-Chih Chang
    4. Shang-Te Danny Hsu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

    1. Amanda L. Peiffer
    2. Julie M. Garlick
    3. Yujin Wu
    4. Matthew B. Soellner
    5. Charles L. Brooks
    6. Anna K. Mapp

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of Nsp1, Nsp2, and Nucleocapsid proteins from SARS-CoV-2

    1. Moriya Slavin
    2. Joanna Zamel
    3. Keren Zohar
    4. Siona Eliyahu
    5. Merav Braitbard
    6. Esther Brielle
    7. Leah Baraz
    8. Miri Stolovich-Rain
    9. Ahuva Friedman
    10. Dana G Wolf
    11. Alexander Rouvinski
    12. Michal Linial
    13. Dina Schneidman-Duhovny
    14. Nir Kalisman

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

    1. Christine Toelzer
    2. Kapil Gupta
    3. Sathish K. N. Yadav
    4. Ufuk Borucu
    5. Andrew D. Davidson
    6. Maia Kavanagh Williamson
    7. Deborah K. Shoemark
    8. Frederic Garzoni
    9. Oskar Staufer
    10. Rachel Milligan
    11. Julien Capin
    12. Adrian J. Mulholland
    13. Joachim Spatz
    14. Daniel Fitzgerald
    15. Imre Berger
    16. Christiane Schaffitzel

    Reviewed by ScreenIT

    2 evaluationsAppears in 1 listLatest version Latest activity

  6. A metal ion orients mRNA to ensure accurate 2’- O ribosyl methylation of the first nucleotide of the SARS-CoV-2 genome

    1. Thiruselvam Viswanathan
    2. Anurag Misra
    3. Siu-Hong Chan
    4. Shan Qi
    5. Nan Dai
    6. Shailee Arya
    7. Luis Martinez-Sobrido
    8. Yogesh K. Gupta

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species

    1. Melvin E. Klegerman
    2. Jeffrey D. Cirillo
    3. David D. McPherson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease

    1. Chew Theng Lim
    2. Kang Wei Tan
    3. Mary Wu
    4. Rachel Ulferts
    5. Lee A. Armstrong
    6. Eiko Ozono
    7. Lucy S. Drury
    8. Jennifer C. Milligan
    9. Theresa U. Zeisner
    10. Jingkun Zeng
    11. Florian Weissmann
    12. Berta Canal
    13. Ganka Bineva-Todd
    14. Michael Howell
    15. Nicola O’Reilly
    16. Rupert Beale
    17. Yogesh Kulathu
    18. Karim Labib
    19. John F.X Diffley

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

    1. Fred D Mast
    2. Peter C Fridy
    3. Natalia E Ketaren
    4. Junjie Wang
    5. Erica Y Jacobs
    6. Jean Paul Olivier
    7. Tanmoy Sanyal
    8. Kelly R Molloy
    9. Fabian Schmidt
    10. Magdalena Rutkowska
    11. Yiska Weisblum
    12. Lucille M Rich
    13. Elizabeth R Vanderwall
    14. Nicholas Dambrauskas
    15. Vladimir Vigdorovich
    16. Sarah Keegan
    17. Jacob B Jiler
    18. Milana E Stein
    19. Paul Dominic B Olinares
    20. Louis Herlands
    21. Theodora Hatziioannou
    22. D Noah Sather
    23. Jason S Debley
    24. David Fenyö
    25. Andrej Sali
    26. Paul D Bieniasz
    27. John D Aitchison
    28. Brian T Chait
    29. Michael P Rout

    • Curated by eLife

      Evaluation Summary:

      The manuscript by Mast et al. describes an impressive collection of new nanobodies against SARS-CoV-2 spike, which probably provides the most complete coverage of the accessible epitopes of spike to date. The authors thoroughly characterize biophysical and functional properties of the nanobodies and set an example of how to best combine multiple nanobodies to target a pathogen. As the latest in a long series of SARS-CoV-2 nanobody papers, this study stands out for its completeness, although it does not provide a novel mechanism of action or biological insights.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    6 evaluationsAppears in 2 listsLatest version Latest activity

  10. A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

    1. Aliakbar Khalili Yazdi
    2. Fengling Li
    3. Kanchan Devkota
    4. Sumera Perveen
    5. Pegah Ghiabi
    6. Taraneh Hajian
    7. Albina Bolotokova
    8. Masoud Vedadi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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