Biochemistry

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

1. Matthew McCallum
2. Nadine Czudnochowski
3. Laura E. Rosen
4. Samantha K. Zepeda
5. John E. Bowen
6. Alexandra C. Walls
7. Kevin Hauser
8. Anshu Joshi
9. Cameron Stewart
10. Josh R. Dillen
11. Abigail E. Powell
12. Tristan I. Croll
13. Jay Nix
14. Herbert W. Virgin
15. Davide Corti
16. Gyorgy Snell
17. David Veesler

Reviewed by ScreenIT

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

1. Nikhil K. Tulsian
2. Palur V. Raghuvamsi
3. Xinlei Qian
4. Gu Yue
5. Bhuvaneshwari D/O Shunmuganathan
6. Firdaus Samsudin
7. Wong Yee Hwa
8. Lin Jianqing
9. Kiren Purushotorman
10. Mary M. Kozma
11. Bei Wang
12. Julien Lescar
13. Cheng-I Wang
14. Ganesh S. Anand
15. Peter J. Bond
16. Paul A. MacAry

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The SARS-CoV-2 nucleocapsid protein preferentially binds long and structured RNAs

1. Christen E. Tai
2. Einav Tayeb-Fligelman
3. Sarah Griner
4. Lukasz Salwinski
5. Jeannette T. Bowler
6. Romany Abskharon
7. Xinyi Cheng
8. Paul M. Seidler
9. Yi Xiao Jiang
10. David S. Eisenberg
11. Feng Guo

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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

1. Neil Bate
2. Christos G. Savva
3. Peter C. E. Moody
4. Edward A. Brown
5. Sian E. Evans
6. Jonathan K. Ball
7. John W. R. Schwabe
8. Julian E. Sale
9. Nicholas P. J. Brindle

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Human 14-3-3 Proteins Site-selectively Bind the Mutational Hotspot Region of SARS-CoV-2 Nucleoprotein Modulating its Phosphoregulation

1. Kristina V. Tugaeva
2. Andrey A. Sysoev
3. Anna A. Kapitonova
4. Jake L.R. Smith
5. Phillip Zhu
6. Richard B. Cooley
7. Alfred A. Antson
8. Nikolai N. Sluchanko

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METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis

1. Enjie Li
2. Mingyue Xia
3. Yu Du
4. Kaili Long
5. Feng Ji
6. Feiyan Pan
7. Lingfeng He
8. Zhigang Hu
9. Zhigang Guo

• Curated by eLife

  Evaluation Summary:

  The potential mechanism of METTL3 N6-methyltransferase in the chemotherapeutic response is poorly defined. Herein, Li and colleagues describe a pathway where METTL3 promoted EGF expression through m6A modification, which further upregulated RAD51 expression, resulting in enhanced HR activity. METTL3 knockdown results in DNA damage accumulation, which renders breast cancer cells sensitive to adriamycin treatment.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The N -Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

1. Yugendar R. Alugubelli
2. Zhi Zachary Geng
3. Kai S. Yang
4. Namir Shaabani
5. Kaustav Khatua
6. Xinyu R. Ma
7. Erol C. Vatansever
8. Chia-Chuan Cho
9. Yuying Ma
10. Lauren Blankenship
11. Ge Yu
12. Banumathi Sankaran
13. Pingwei Li
14. Robert Allen
15. Henry Ji
16. Shiqing Xu
17. Wenshe Ray Liu

Reviewed by ScreenIT

The P3 O - Tert -Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

1. Yuying Ma
2. Kai S. Yang
3. Zhi Zachary Geng
4. Yugendar R. Alugubelli
5. Namir Shaabani
6. Erol C. Vatansever
7. Xinyu R. Ma
8. Chia-Chuan Cho
9. Kaustav Khatua
10. Lauren Blankenship
11. Ge Yu
12. Banumathi Sankaran
13. Pingwei Li
14. Robert Allen
15. Henry Ji
16. Shiqing Xu
17. Wenshe Ray Liu

Reviewed by ScreenIT

SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion

1. Dhiraj Mannar
2. James W. Saville
3. Xing Zhu
4. Shanti S. Srivastava
5. Alison M. Berezuk
6. Katharine S. Tuttle
7. Citlali Marquez
8. Inna Sekirov
9. Sriram Subramaniam

Reviewed by ScreenIT

Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro : insights into structural requirements for binding

1. Sabrina Bertini
2. Anna Alekseeva
3. Stefano Elli
4. Isabel Pagani
5. Serena Zanzoni
6. Giorgio Eisele
7. Ravi Krishnan
8. Klaus P Maag
9. Christian Reiter
10. Dominik Lenhart
11. Rudolf Gruber
12. Edwin A Yates
13. Elisa Vicenzi
14. Annamaria Naggi
15. Antonella Bisio
16. Marco Guerrini

Reviewed by ScreenIT