Allergy and Immunology

ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis

1. Stephanie Guillet
2. Tomi Lazarov
3. Natasha Jordan
4. Bertrand Boisson
5. Maria Tello
6. Barbara Craddock
7. Ting Zhou
8. Chihiro Nishi
9. Rohan Bareja
10. Hairu Yang
11. Frederic Rieux-Laucat
12. Rosa Irene Fregel Lorenzo
13. Sabrina D Dyall
14. David Isenberg
15. David D'Cruz
16. Nico Lachmann
17. Olivier Elemento
18. Agnes Viale
19. Nicholas D Socci
20. Laurent Abel
21. Shigekazu Nagata
22. Morgan Huse
23. W Todd Miller
24. Jean-Laurent Casanova
25. Frédéric Geissmann

• Curated by eLife

  eLife assessment

  In this important study, the authors found, with the use of statistical methods, that compound heterozygous rare deletion variants affecting the kinase-domain of non-receptor tyrosine kinase TNK2/ACK1 and PTK6/BRK are associated with human systemic lupus erythematosus (SLE). The authors use a convincing mouse experimental model and human-induced pluripotent stem cell (hiPSC)-derived macrophages to clarify cause-effect relationships and the cellular basis of nephritis. With the identification of new SLE-related genes, this manuscript improves our understanding of human SLE pathogenesis.

Reviewed by eLife

The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination

1. Doan C. Nguyen
2. Ian T. Hentenaar
3. Andrea Morrison-Porter
4. David Solano
5. Natalie S. Haddad
6. Carlos Castrillon
7. Pedro A. Lamothe
8. Joel Andrews
9. Danielle Roberts
10. Sagar Lonial
11. Ignacio Sanz
12. F. Eun-Hyung Lee

Reviewed by Rapid Reviews Infectious Diseases

The assembly of neutrophil inflammasomes during COVID-19 is mediated by type I interferons

1. Luz E. Cabrera
2. Suvi T. Jokiranta
3. Sanna Mäki
4. Simo Miettinen
5. Ravi Kant
6. Lauri Kareinen
7. Tarja Sironen
8. Jukka-Pekka Pietilä
9. Anu Kantele
10. Eliisa Kekäläinen
11. Hanna Lindgren
12. Pirkko Mattila
13. Anja Kipar
14. Olli Vapalahti
15. Tomas Strandin

Reviewed by Review Commons

Specific long‐term changes in anti‐SARS‐CoV‐2 IgG modifications and antibody functions in mRNA, adenovector, and protein subunit vaccines

1. Sebastian Reinig
2. Chin Kuo
3. Chia‐Chun Wu
4. Sheng‐Yu Huang
5. Jau‐Song Yu
6. Shin‐Ru Shih

Reviewed by PREreview

A streamlined whole blood CyTOF workflow defines a circulating immune cell signature of COVID ‐19

1. Daniel Geanon
2. Brian Lee
3. Edgar Gonzalez‐Kozlova
4. Geoffrey Kelly
5. Diana Handler
6. Bhaskar Upadhyaya
7. John Leech
8. Ronaldo M. De Real
9. Manon Herbinet
10. Assaf Magen
11. Diane Del Valle
12. Alexander Charney
13. Seunghee Kim‐Schulze
14. Sacha Gnjatic
15. Miriam Merad
16. Adeeb H. Rahman

Reviewed by ScreenIT

Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

1. Rita Carsetti
2. Salvatore Zaffina
3. Eva Piano Mortari
4. Sara Terreri
5. Francesco Corrente
6. Claudia Capponi
7. Patrizia Palomba
8. Mattia Mirabella
9. Simona Cascioli
10. Paolo Palange
11. Ilaria Cuccaro
12. Cinzia Milito
13. Alimuddin Zumla
14. Markus Maeurer
15. Vincenzo Camisa
16. Maria Rosaria Vinci
17. Annapaola Santoro
18. Eleonora Cimini
19. Luisa Marchioni
20. Emanuele Nicastri
21. Fabrizio Palmieri
22. Chiara Agrati
23. Giuseppe Ippolito
24. Ottavia Porzio
25. Carlo Concato
26. Andrea Onetti Muda
27. Massimiliano Raponi
28. Concetta Quintarelli
29. Isabella Quinti
30. Franco Locatelli

Reviewed by ScreenIT

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

1. Panagiotis Skendros
2. Alexandros Mitsios
3. Akrivi Chrysanthopoulou
4. Dimitrios C. Mastellos
5. Simeon Metallidis
6. Petros Rafailidis
7. Maria Ntinopoulou
8. Eleni Sertaridou
9. Victoria Tsironidou
10. Christina Tsigalou
11. Maria Tektonidou
12. Theocharis Konstantinidis
13. Charalampos Papagoras
14. Ioannis Mitroulis
15. Georgios Germanidis
16. John D. Lambris
17. Konstantinos Ritis

Reviewed by ScreenIT

Plasma From Recovered COVID-19 Patients Inhibits Spike Protein Binding to ACE2 in a Microsphere-Based Inhibition Assay

1. Edward P Gniffke
2. Whitney E Harrington
3. Nicholas Dambrauskas
4. Yonghou Jiang
5. Olesya Trakhimets
6. Vladimir Vigdorovich
7. Lisa Frenkel
8. D Noah Sather
9. Stephen E P Smith

Reviewed by ScreenIT

Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

1. Nils Rother
2. Cansu Yanginlar
3. Rik G.H. Lindeboom
4. Siroon Bekkering
5. Mandy M.T. van Leent
6. Baranca Buijsers
7. Inge Jonkman
8. Mark de Graaf
9. Marijke Baltissen
10. Lieke A. Lamers
11. Niels P. Riksen
12. Zahi A. Fayad
13. Willem J.M. Mulder
14. Luuk B. Hilbrands
15. Leo A.B. Joosten
16. Mihai G. Netea
17. Michiel Vermeulen
18. Johan van der Vlag
19. Raphaël Duivenvoorden

Reviewed by ScreenIT

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

1. Lucie Rodriguez
2. Pirkka T. Pekkarinen
3. Tadepally Lakshmikanth
4. Ziyang Tan
5. Camila Rosat Consiglio
6. Christian Pou
7. Yang Chen
8. Constantin Habimana Mugabo
9. Ngoc Anh Nguyen
10. Kirsten Nowlan
11. Tomas Strandin
12. Lev Levanov
13. Jaromir Mikes
14. Jun Wang
15. Anu Kantele
16. Jussi Hepojoki
17. Olli Vapalahti
18. Santtu Heinonen
19. Eliisa Kekäläinen
20. Petter Brodin

Reviewed by ScreenIT