Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N ‑acetylamino malonic acid monoesters
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The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N -acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides access to N -sulfonyl, N -benzoyl, and N -Boc-protected 2-aminoproline derivatives.