Entry to 2-Aminoprolines via Electrochemical Decarboxylative Amidation of N ‑Acetylamino Malonic Acid Monoesters
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Electrochemical synthesis of 2-aminoprolines capitalizes on anodic decarboxylation-intramolecular amidation of readily available N -acetylamino malonic acid monoesters. The decarboxylative amidation under Hofer−Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides an access to N -sulfonyl, N -benzoyl, and N -Boc-protected 2-aminoproline derivatives.