Palladium (II)-Catalyzed 2-(Phenylseleninyl) quinoxalines Synthesis via a Tandem Reaction of C-S Bond Direct Cross-Coupling/Sulfonylation
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A palladium (II)-catalyzed tandem reaction of C-S bond direct cross-coupling/sulfonylation has been developed. Starting from substituted quinoxalines and substituted phenylthiophenols versatile biologically active 2-(phenylsulfinyl)-6,7-dihydroquinoxaline derivatives and 1-methyl-2-(phenylsulfinyl)-1H-pyrrole derivatives were efficiently synthesized. The reaction mechanism was studied by the deuterium isotope experiments. This protocol features were under mild reaction conditions, wider substrate scope and provides an economical approach toward C(sp2)-sulfoxide bond formation.