Murburn theorization for cellular/organellar trans-membrane potential

The long-standing “intelligent membrane” electrogenically pumping and channelling cations (sponsored by proteins’ binding-based selectivity) was critiqued by many physicists’ groups earlier. Since the 2020s, my group’s pursuits had afforded an alternate view for cellular electrophysiology, founded in murburn concept. Murburn concept is a new theorization which postulates that effective charge separation (ECS) forms the fundamental drive for doing useful work in/by cells, obligatorily leading to the production/utilization of diffusible reactive (oxygen) species (DRS/DROS) in the process, which govern the cellular powering, coherence, homeostasis, electro-mechanical and sensing-response (PCHEMS) activities, enabling the cells to work as simple chemical engines (ECS). In this communication, I drive in the last few nails on the coffin of “intelligent membrane” theorization and provide the first tangible mathematical model to explain the resting trans-membrane potential (TMP) in a cell/neuron.