Seamless chemo-electrical and radiative interfacing of ‘living organic systems’ with ‘man-made electro-mechanical components’ via murburn concept

Hitherto, life-sustaining mechanisms were primarily understood within the purview of: (i) intelligent cellular/organellar membranes guarding/maintaining their internal milieu deterministically, and (ii) the cellular activities being governed by directional information-flow via the central dogma. In this schema, cellular coherence (inter-molecular networking to achieve functional unitization) and homeostasis/electrophysiology was explained by the concentration-dependent interaction dynamics of catalytic enzymes-substrates, electron donors-acceptors, signalling receptors-ligands, channels-ions, antibodies-antigens, etc. Such treatments entailed selective/specific and topology-based (affinity-driven) stoichiometric interactions. Also, only the impact of external radiations (like X-rays, UV-Vis-IR light, micro/radio waves, etc.) on living systems have found prominence in biomedical literature, with lesser information on internally generated or readdressed low/high-frequency radiations. The above long-standing paradigm has witnessed a major upheaval in the last decade with the unravelling of murburn concept, which postulates that diffusible reactive species (DRS) and murzymes (proteins that recruit DRS in routine functions) are a fundamental pivot of life that aid catalytic moiety-/electron-transfers, phase-changes, post-translational modifications, etc. within the cells, thereby serving diverse agenda of its function. The murburn theorization solicits stochastic and variable “molecule-unbound ion-radical/radiation interactions”, provides adequate energy differentials for powering cellular processes, and explains why oxygen became the elixir of life. Herein, we project tangible framework/examples of how murburn concept could afford a seamless interlacing of man-made synthetic components with biological systems, particularly within the contexts of bioenergetic, metabolic and sensing-response agenda. We also discuss mandates wherein analog-digital conversions could be achieved, and project the scope and limitations of murburn-based approach in futuristic bionic-cyborg technology.