Effect of ulinastatin combined with intensive psychological intervention on anxiety, depression and inflammatory reaction in patients with acute respiratory distress syndrome

Objective: The purpose of this study is to analyze the impact of ulinastatin and a rigorous psychosocial program on reducing inflammation, depressive symptoms, and anxiety in patients with acute respiratory distress syndrome. Methods: A total of 113 people who were admitted to our hospital with acute respiratory distress syndrome between April 2020 and December 2021 were selected as subjects. Based on the different treatment methods, they were separated into a control group (n=57) and an experimental group (n=56). The individuals in the control group were given standard care. Ulinastatin was administered to intervention group participants in addition to intensive psychosocial assistance. The inflammation and unfavorable emotions were evaluated before and after therapy in both groups. Results: Gender, age, medical history, body mass index, and other demographic data did not differ significantly ( P > 0.05) across the groups. Before treatment, there were no statistically significant differences between the two groups in terms of inflammatory markers, blood gas levels, or evaluations of poor mood ( P >0.05). Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1β), and interleukin-6 (IL-6) levels were lower in the experimental group than that in the control group after therapy. Even though the control group had better oxygenation (lower PaCO ₂ , higher PaO ₂ , higher Oxygenation Index; OI) and higher Oxygenation Factor (OF), the experimental group showed greater levels of interferon-γ (IFN-γ). The experimental group also showed higher levels of the self-rating Anxiety Scale (Self-rating Anxiety Scale) than the control group did. Besides, the scores of the Beck Depression Inventory (BDI) and the Self-Rating Depression Scale (SDS) reduced considerably ( P <0.05) compared to those of the control group. Conclusion: Ulinastatin combined with intensive psychological intervention can effectively treat patients with acute respiratory distress syndrome, reduce the complications of inflammation, and manage the patients' unpleasant emotions, so as to obtain good treatment effect.