The Impact of Hypomagnesemia on the Prognosis of Elderly Patients with Sepsis

Objective To evaluate the association between hypomagnesemia and in-hospital all-cause mortality in elderly patients with sepsis. Methods A retrospective analysis was performed on elderly patients (60–80 years old) with sepsis admitted to the Department of Critical Care Medicine of our hospital from August 2022 to July 2024. Eligible patients were divided into the hypomagnesemia group (serum magnesium < 1.46 mg/dL) and the normal magnesium group based on their serum magnesium levels at admission. The mortality difference between the two groups was compared, and univariate analysis was first conducted followed by multivariate Logistic regression to identify independent risk factors for in-hospital mortality. Results A total of 255 elderly patients were included, with 99 in the hypomagnesemia group. The mortality rate of the hypomagnesemia group was 34.3%, which was significantly higher than that of the normal magnesium group (9.0%), with a statistically significant difference (p < 0.05). High Sequential Organ Failure Assessment (SOFA) score, mechanical ventilation, and hypomagnesemia were independent risk factors for in-hospital all-cause mortality in elderly patients with sepsis (OR = 2.63, 2.14, 3.01, all p < 0.05). Conclusion Hypomagnesemia is an independent risk factor for in-hospital all-cause mortality in elderly patients with sepsis. Attention should be paid to maintaining normal serum magnesium levels during the management of these patients.