Design of a 1% Ni, S-Doped TiO₂ Heterogeneous Nano-catalyst for Catalytic Synthesis of Benzoxazole Derivatives

A heterogeneous nanocatalyst made from 1% Ni, S doped titanium dioxide (TiO2) was used in developing a green and efficient synthesis of benzoxazole derivatives via an environmentally sustainable and a solvent-free condensation reaction between 2-aminophenol and aromatic aldehydes. Characterization of the catalyst included FT-IR, XRD, SEM, and EDS analysis as well as determination of its catalytic activity. The catalyst showed good thermal stability and was able to be reused 5 times with minimal loss in activity. Overall, this new catalytic system represents a viable alternative for benzoxazole synthesis due to several advantages such as being environmentally compatible, low cost, easy to work with and reusable.