Assessment of Quality of Life in Children with Systemic Lupus Erythematous Who Suffering from Depression and Anxiety and Its Relation to the Activity of the Disease

Aim of the Work: Clarify the relationship between mental disorders as depression, anxiety and Systemic Lupus Erythematous activity. Study their effect on the quality of life in children with Systemic Lupus Erythematous. Study Design: Cross-sectional study. Place and Duration of Study: nephrology and rheumatology unit in pediatric department, faculty of medicine- Tanta University and at child psychiatry outpatients in center of psychiatry, neurology and neurosurgery- Tanta University . From February 2024 till July 2024. Methodology: This study was Cross sectional study It was performed on 80 patients with SLE who are further divided to subgroups (9) patients diagnosed as SLE in activity, patients with activity {mild (29), moderate (25) & severe (17)} . All subjects aged from (18-65) years old. This study was Cross sectional study It was performed on 80 patients with SLE who are further divided to subgroups (9) patients diagnosed as SLE in activity, patients with activity {mild (29), moderate (25) & severe (17)} . All subjects aged from (18-65) years old. By using psychometric scales e.g. Pediatric Quality of Life (PedsQL), the Children's Depression Inventory (CDI) and the Revised Child Anxiety and Depression Scale-Short Version. All subjects aged from (18-65) years old. Results: It was found that the average score for CDI is (14±8.2); 47.5% of the studied group was normal, the prevalence of clinically significant depression (CDI > 15) was 52.5% that was further divided to 26.3% had mild depression, 18.8% had moderate depression& 7.5% had severe depression. There was positive correlation with statistically significant value between CDI grades& pediatric quality of life scores. Conclusion: The high prevalence of anxiety and depression in SLE and its detrimental effects on quality of life are the study's key results.