Neuropsychiatric Manifestations in Pediatric Systemic Lupus Erythematosus: A Clinical Study from a Mexican Pediatric Hospital

  1. SOFIA B. VÁZQUEZ MAZANARES
  2. DIANA MOLINA VALDESPINO
  3. SILVESTRE GARCÍA DE LA PUENTE
  4. OSCAR SÁNCHEZ GUERRERO
  5. ANA L. RODRÍGUEZ LOZANO
  6. FRANCISCO E. RIVAS LARRAURI
  7. JESÚS RAMÍREZ BERMÚDEZ
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Abstract

Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major cause of morbidity in pediatric systemic lupus erythematosus (pSLE). This study aimed to describe the frequency and characteristics of neuropsychiatric manifestations in patients aged 8–17 years with pSLE treated at a tertiary pediatric hospital in Mexico. Methods: Prospective cross-sectional study with MINI-KID evaluation and structured mental examination. Additional data included labs, EEG, EKG, and imaging. Results: Neuropsychiatric manifestations occurred in 39% of patients. Most common symptoms were anxiety, headache, depression, cognitive impairment, seizures, and delirium. Conclusion: Early detection is essential to avoid neurocognitive sequelae and functional impairment.

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  1. Version published to 10.21203/rs.3.rs-8497467/v1 on Research Square