Association of Inflammatory Biomarkers with Subclinical Cardiac Dysfunction in Inflammatory Bowel Disease: Roles of NLR, PLR, CRP/Alb, and MPV

Background: Inflammatory bowel disease (IBD) has an increased cardiovascular risk, but the relationship between systemic inflammation and subclinical cardiac dysfunction is poorly understood. The present research had the objective of investigating the relationships between inflammatory biomarkers and cardiac parameters in IBD patients. Methods: A cross-sectional study comprised 110 IBD patients who were evaluated for hematological indices (NLR, PLR, CRP/Albumin ratio, MPV) and echocardiographic indices. Disease severity was staged according to Truelove-Witts criteria. Statistical analysis included ANOVA and correlation tests. Results: The population studied was consisting of 47 females (42.7%) and 63 males (57.3%). The mean age was 42.15 ± 13.23 years. Findings showed a significantly increase in NLR and MPV in more severe disease (p<0.001). A significantly correlation was observed between CRP/albumin ratio and LVEDVI (r=0.21, p=0.044), and between NLR and QT interval (r=0.31, p=0.005), Also statistically significant correlation between QT Interval with NLR, PR Interval with PLR, and MPV with PR Interval. Left ventricular ejection fraction (LVEF) averaged 53.53±5.34%, within the normal range (≥50%), though some patients showed significant reduction (minimum 25%). Discussion: Inflammatory biomarkers exhibit distinct cardiac associations: NLR with repolarization, MPV/PLR with conduction, and CRP/Albumin with remodeling. The findings suggest the promise of biomarkers in the identification of IBD patients at risk of subclinical cardiac involvement and the requirement for longer-term validation.