A bibliometric analysis of immunotherapy in glioblastoma

Background The glioblastoma (GBM) is a type of cancer of the nervous system that has a high mortality rate. The tumor microenvironment (TME) is complicated and flexible, and immunotherapy is often used to alter the microenvironment. Researchers are exploring ways to boost survival through immunotherapy. There is, however, a lack of comprehensive trend analysis. An analysis of bibliometrics can provide insight into this problem by visualizing research patterns. A study was conducted to map these trends between 2005 and 2024 in GBM immunotherapy. Methods Within the Web of Science Core Collection, spanning 2005 to 2024, an immunotherapy search was conducted on GBM. This search provides an insight into the current state of research in this field, despite its narrow focus. The following software programs were used for the bibliometric analysis: VOS viewer, Cite space, Scimago Graphica, and R-software. Results A total of 2064 publications have been published in this field between 2005 and 2024, most of them coming from China and the United States. According to co-citation counts, Roger Stupp is the most valuable contributing author. Frontiers in Oncology holds the top publication volume spot. The clinical community has a keen interest in researching nivolumab and chemotherapy, as seen by keyword burst analysis, which suggests that neoadjuvant immunotherapy represents a promising therapeutic avenue in the future. Conclusions This study summarized current trends in immunotherapy aspects of GBM and the research frontiers. As a useful reference and source of new insight into this area of research, this summary can be very valuable.