Global trends in colorectal cancer and tumor microenvironment research: a bibliometric and visualization analysis
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Background: Colorectal cancer is a common malignancy worldwide, and its incidence and mortality are increasing annually. In recent years, researchers have gradually realized that the tumor microenvironment plays a crucial role in the development and progression of colorectal cancer. The in-depth study of CRC and its microenvironment provides not only a new perspective understanding the occurrence and development of tumors, but also potential new strategies for clinical treatment. Methods: The Web of Science Core Collection (WoSCC) was used to retrieve literature related to colorectal cancer and the tumor microenvironment. CiteSpace software and VOSviewer software were used to evaluate and visualize the authors, journals, institutions, countries, keywords and citations. To explore the research hotspots and potential development trends in this field. Results: A total of 7080 relevant articles were analyzed, and the number of published articles tended to increase. The countries and institutions that have contributed the most to this field are China and Sun Yat Sen University. Van de Velde, C was the most prolific author and the most cited literature was Sung, Hyuna's article " Global cancer statistics 2020 " published in the CA-A CANCER JOURNAL FOR CLINICIANS. The journals with the most published articles and citations were CANCERS and Clinical cancer research, respectively. Keyword analysis revealed that the current popular research topics included the "immune microenvironment", "immune filtration", "metabolism" and "landscape". Conclusions: The study of colorectal cancer and the tumor microenvironment is still a hot topic. Future research will focus more on the interaction between various immune cells and molecules, study the expression of cancer-related genes and proteins, and explore new therapeutic targets and prognostic markers. These findings provide strong support for the precise and individualized treatment of cancer.
