The Association Between Atherogenic Index of plasma and Serum Uric Acid: A Cross-Sectional Study

Metabolic diseases are significantly correlated with the Atherogenic Index of Plasma (AIP). However, there is currently no conclusive data establishing a direct connection between AIP and serum uric acid (SUA) levels. Data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007 to 2016 were used in this cross-sectional investigation. 10,247 people in all participated in the study. By using the logarithm (base 10) of the ratio of triglycerides to high-density lipoprotein cholesterol, AIP was calculated. The concentration of SUA was the dependent variable. The connection between AIP and SUA levels was tested using a multi-factor logistic regression model and a limited three-sample technique. Sub-group analysis and interaction testing were also carried out. In the completely adjusted model, the study found a curvilinear relationship between AIP and the chance of higher SUA levels. Serum uric acid (SUA) levels were directly correlated with an increase in AIP values when the atherogenic index of plasma (AIP) was less than 0.81. Nevertheless, serum uric acid (SUA) levels consistently decreased with increasing AIP values when the atherogenic index of plasma (AIP) exceeded 0.81. Moreover, the probability of having high SUA levels was significantly higher in those in the top 25% of AIP than in those in the lowest 25% of AIP (β = 0.6195, 95% CI: 0.54–0.68, P < 0.001). This association was consistent for every category.there is an inverted U-shaped nonlinear relationship between SUA levels and AIP among adult US population. This suggests that higher AIP levels could lead to higher SUA levels.