C-Reactive Protein to Lymphocyte Ratio is associated with asthma risk:A Cross-Sectional Study

BACKGROUND CLR, a recently identified inflammatory biomarker, has been associated with various inflammatory conditions. Asthma is an inflammatory airway disease heavily influenced by inflammation. The primary goal of this study was to examine the impact of CLR on the risk of asthma. Methods This study conducted a retrospective analysis of 22,339 participants from the NHANES dataset between 1999 and 2010. To investigate the relationship between CLR and asthma risk, we employed logistic regression and restricted cubic spline analysis. Additionally, subgroup and sensitivity analyses were performed to validate the robustness of the identified associations. Results Analysis using a multivariate logistic regression models revealed a significant positive correlation between ln-transformed CLR and asthma risk (OR: 1.07,95% CI 1.03–1.11; P < 0.001). Compared to participants in the first tertile of ln-transformed CLR values ( T1), those in the T2 and T3 showed increased asthma risk by 1.07 times and 1.21 times, respectively. The risk demonstrated a statistically significant upward trend with higher ln-transformed CLR (trend test P < 0.001). RCS analysis confirmed no nonlinear relationship between CLR values and asthma risk. Subgroup and sensitivity analyses further validated the robustness and consistency of these findings. Conclusions As the CLR level improved, the risk of asthma increased correspondingly, exhibiting a linear correlation.