Drug-Induced Glucose Metabolism Disorders: Role of Aryl Hydrocarbon Receptor

  1. Alevtina Y. Grishanova
  2. Maria L. Perepechaeva

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Abstract

Pharmacological compounds can disrupt glucose homeostasis, leading to impaired glucose tolerance, hyperglycemia, or newly diagnosed diabetes, as well as worsening glycemic control in patients with pre-existing diabetes. Traditional risk factors alone cannot explain the rapidly growing global incidence of diabetes. Therefore, prevention of insulin resistance could represent an effective strategy. Achieving this goal requires a deeper understanding of the mechanisms underlying the development of insulin re-sistance, with particular attention to the aryl hydrocarbon receptor (AhR). AhR, a transcription factor functioning as a xenobiotic sensor, plays a key role in various molecular pathways regulating normal homeostasis, organogenesis, and immune function. Activated by a range of exogenous and endogenous ligands, AhR is involved in the regulation of glucose and lipid metabolism as well as insulin sensitivity. However, current findings remain contradictory regarding whether AhR activation exerts beneficial or detrimental effects. This review summarizes recent studies exploring the role of the AhR pathway in insulin secretion and glucose homeostasis across different tissues, and discusses molecular mechanisms involved in this process. Considering that several drugs act as AhR ligands, the review also compares how these ligands affect metabolic pathways of glucose and lipid metabolism and insulin sensitivity, producing either positive or negative effects.

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  1. PREreview

    This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/17682387.

    Does the introduction explain the objective of the research presented in the preprint? Yes It clearly explain the topic "Drug-Induced Glucose Metabolism Disorders: Role of Aryl Hydrocarbon Receptor" is a review work trying to see the effect of drug in glucose metablism disorder and the role Aryl Hydrocarbon receptor place in this process
    Are the methods well-suited for this research? I don't know
    Are the conclusions supported by the data? Highly supported The work is a review and the conclusion highly supported research that has been done in the space in the time past.
    Are the data presentations, including visualizations, well-suited to represent the data? I don't know
    How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research? Very clearly The explanation was very clear and show the interplay between different mechanism
    Is the preprint likely to advance academic knowledge? Highly likely Yes it shows regors of different research work that has been done
    Would it benefit from language editing? No
    Would you recommend this preprint to others? Yes, it's of high quality The paper highlighted the role of drug -induced glucose metabolic disorder and it an essential study to know the gene associated disorder especially for patient
    Is it ready for attention from an editor, publisher or broader audience? Yes, after minor changes More visuals would help the work more friendly and can reach target audience

    Competing interests

    The author declares that they have no competing interests.

    Use of Artificial Intelligence (AI)

    The author declares that they did not use generative AI to come up with new ideas for their review.

  2. Version published to 10.20944/preprints202511.0484.v1