Comparative study of the clinical characteristics and epidemiological trend of 244 COVID-19 infected children with or without GI symptoms

  1. Xiao-li Xiong
  2. Kenneth Kak-yuen Wong
  3. Shui-qing Chi
  4. Ai-fen Zhou
  5. Jian-qiao Tang
  6. Li-shan Zhou
  7. Patrick Ho-yu Chung
  8. Gilbert Chua
  9. Ketih Tung
  10. Ian Wong
  11. Celine Chui
  12. Xue Li
  13. Mike Yat-wah Kwan
  14. Wilfred Hing-sang Wong
  15. Marco Hok-kung Ho
  16. Godfrey Chi-fung Chan
  17. Guo-qing Cao
  18. Kang Li
  19. Patrick Ip
  20. Peng Chen
  21. Shao-tao Tang
  22. Paul Kwong-hang Tam

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Abstract

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  1. ScreenIT

    SciScore for 10.1101/2020.04.29.20084244: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Study design and patients: This was a retrospective single-center study approved by the Research Ethics Board of Wuhan Children’s Hospital (WHCH2020022).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The data was analyzed by SPSS 26.0, and P<0.05 was used to determine significance.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are limitations of this study. This is a retrospective cohort study so we may not be able to establish any causal relationship. The sample size of patients with GI symptoms is relatively small, due to its low incidence so we may miss out some risk factors for its occurrence. The laboratory examinations and fecal SARS-CoV-2 RNA detection were not done in all patients and this may generate bias in the data analysis. Our study is one of the largest of its kind, and we showed the differences between clinical and laboratory characteristics of patients with or without GI symptoms, which were different from adults. Both pediatricians and patients need to pay more attention to COVID-19 children with GI symptoms even though they have mild symptoms and stable vital signs. An upward trend in asymptomatic infections also means the public should be on guard at all times.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1136/gutjnl-2020-321486
  3. Version published to 10.1101/2020.04.29.20084244v1 on medRxiv