Longitudinal, Multi-Platform Metagenomics Yields a High-Quality Genomic Catalog and Guides an In Vitro Model for Cheese Communities
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Abstract
Metagenome sequencing can provide great insights into microbiome composition and function and help researchers develop testable hypotheses. Model microbiomes, such as those composed of cheese rind bacteria and fungi, allow the testing of these hypotheses in a controlled manner.
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Super exciting work! I was especially intrigued by your report of a very large prophage (~300 kb). I would recommend double checking that result manually by looking at the contig and the gene content of the putative prophage, as virus finders can have false positives and can incorrectly call the borders of prophages, especially if they are integrated into a lot of other mobile DNA. If the prophage really is ~300 kb, that would be super exciting! Large phages are often lytic or pseudolysogenic (ie dont integrate), and prophages tend to be small relative to non-integrating phage. what a lovely paper!
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Super exciting work! I was especially intrigued by your report of a very large prophage (~300 kb). I would recommend double checking that result manually by looking at the contig and the gene content of the putative prophage, as virus finders can have false positives and can incorrectly call the borders of prophages, especially if they are integrated into a lot of other mobile DNA. If the prophage really is ~300 kb, that would be super exciting! Large phages are often lytic or pseudolysogenic (ie dont integrate), and prophages tend to be small relative to non-integrating phage. what a lovely paper!
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