Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis
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eLife Assessment
This study makes a novel and valuable contribution by adapting step selection functions, traditionally used in animal ecology, to explore human movement and environmental risk exposure in urban slums, offering a promising framework for spatial epidemiology, particularly regarding leptospirosis. The integration of GPS telemetry with environmental data and the stratification by gender and serostatus are notable strengths that enhance the study's relevance for public health applications. The strength of evidence is compelling.
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Abstract
Human movement plays a critical role in the transmission of infectious diseases, especially those with environmental drivers like leptospirosis—a zoonotic bacterial infection linked to mud and water contact. Using GPS loggers, we collected detailed telemetry data to understand how fine-scale movements can be analysed in the context of an infectious disease. We recruited individuals living in urban slums in Salvador, Brazil to analyse how they interact with environmental risk factors such as domestic rubbish piles, open sewers, and a local stream. We aimed to identify differences in movement patterns inside the study areas by gender, age, and leptospirosis serological status. Step-selection functions, a spatio-temporal model used in animal movement ecology, estimated selection coefficients to represent the likelihood of movement toward specific environmental factors. With 124 participants wearing GPS devices for 24 to 48 hours, recording locations every 35 seconds during active daytime hours, we segmented movements into morning, midday, afternoon, and evening. Our results suggested women moved closer to the central stream and farther from open sewers compared to men, while serologically positive individuals avoided open sewers. This study introduces a novel method for analysing human telemetry data in infectious disease research, providing critical insights for targeted interventions.
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eLife Assessment
This study makes a novel and valuable contribution by adapting step selection functions, traditionally used in animal ecology, to explore human movement and environmental risk exposure in urban slums, offering a promising framework for spatial epidemiology, particularly regarding leptospirosis. The integration of GPS telemetry with environmental data and the stratification by gender and serostatus are notable strengths that enhance the study's relevance for public health applications. The strength of evidence is compelling.
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Reviewer #1 (Public review):
Summary:
The study investigated how individuals living in urban slums in Salvador, Brazil, interact with environmental risk factors, particularly focusing on domestic rubbish piles, open sewers, and a central stream. The study makes use of the step selection functions using telemetry data, which is a method to estimate how likely individuals move towards these environmental features, differentiating among groups by gender, age, and leptospirosis serostatus. The results indicated that women tended to stay closer to the central stream while avoiding open sewers more than men. Furthermore, individuals who tested positive for leptospirosis tended to avoid open sewers, suggesting that behavioral patterns might influence exposure to risk factors for leptospirosis, hence ensuring more targeted interventions.
Strengt…
Reviewer #1 (Public review):
Summary:
The study investigated how individuals living in urban slums in Salvador, Brazil, interact with environmental risk factors, particularly focusing on domestic rubbish piles, open sewers, and a central stream. The study makes use of the step selection functions using telemetry data, which is a method to estimate how likely individuals move towards these environmental features, differentiating among groups by gender, age, and leptospirosis serostatus. The results indicated that women tended to stay closer to the central stream while avoiding open sewers more than men. Furthermore, individuals who tested positive for leptospirosis tended to avoid open sewers, suggesting that behavioral patterns might influence exposure to risk factors for leptospirosis, hence ensuring more targeted interventions.
Strengths:
(1) The use of step selection functions to analyze human movement represents an innovative adaptation of a method typically used in animal ecology. This provides a robust quantitative framework for evaluating how people interact with environmental risk factors linked to infectious diseases (in this case, leptospirosis).
(2) Detailed differentiation by gender and serological status allows for nuanced insights, which can help tailor targeted interventions and potentially improve public health measures in urban slum settings.
(3) The integration of real-world telemetry data with epidemiological risk factors supports the development of predictive models that can be applied in future infectious disease research, helping to bridge the gap between environmental exposure and health outcomes.
Weaknesses:
(1) The sample size for the study was not calculated, although it was a nested cohort study.
(2) The step‐selection functions, though a novel method, may face challenges in fully capturing the complexity of human decision-making influenced by socio-cultural and economic factors that were not captured in the study.
(3) The study's context is limited to a specific urban slum in Salvador, Brazil, which may reduce the generalizability of its findings to other geographical areas or populations that experience different environmental or socio-economic conditions.
(4) The reliance on self-reported or telemetry-based movement data might include some inaccuracies or biases that could affect the precision of the selection coefficients obtained, potentially limiting the study's predictive power.
(5) Some participants with less than 50 relocations within the study area were excluded without clear justification, see line 149.
(6) Some figures are not clear (see Figure 4 A & B).
(7) No statement on conflict of interest was included, considering sponsorship of the study.
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Reviewer #2 (Public review):
Summary:
Pablo Ruiz Cuenca et al. conducted a GPS logger study with 124 adult participants across four different slum areas in Salvador, Brazil, recording GPS locations every 35 seconds for 48 hours. The aim of their study was to investigate step-selection models, a technique widely used in movement ecology to quantify contact with environmental risk factors for exposure to leptospires (open sewers, community streams, and rubbish piles). The authors built two different types of models based on distance and based on buffer areas to model human environmental exposure to risk factors. They show differences in movement/contact with these risk factors based on gender and seropositivity status. This study shows the existence of modest differences in contact with environmental risk factors for leptospirosis at …
Reviewer #2 (Public review):
Summary:
Pablo Ruiz Cuenca et al. conducted a GPS logger study with 124 adult participants across four different slum areas in Salvador, Brazil, recording GPS locations every 35 seconds for 48 hours. The aim of their study was to investigate step-selection models, a technique widely used in movement ecology to quantify contact with environmental risk factors for exposure to leptospires (open sewers, community streams, and rubbish piles). The authors built two different types of models based on distance and based on buffer areas to model human environmental exposure to risk factors. They show differences in movement/contact with these risk factors based on gender and seropositivity status. This study shows the existence of modest differences in contact with environmental risk factors for leptospirosis at small spatial scales based on socio-demographics and infection status.
Strengths:
The authors assembled a rich dataset by collecting human GPS logger data, combined with field-recorded locations of open sewers, community streams, and rubbish piles, and testing individuals for leptospirosis via serology. This study was able to capture fine-scale exposure dynamics within an urban environment and shows differences by gender and seropositive status, using a method novel to epidemiology (step selection).
Weaknesses:
Due to environmental data being limited to the study area, exposure elsewhere could not be captured, despite previous research by Owers et al. showing that the extent of movement was associated with infection risk. Limitations of step selection for use in studying human participants in an urban environment would need to be explicitly discussed.
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Author response:
Reviewer #1 (Public review):
Summary:
The study investigated how individuals living in urban slums in Salvador, Brazil, interact with environmental risk factors, particularly focusing on domestic rubbish piles, open sewers, and a central stream. The study makes use of the step selection functions using telemetry data, which is a method to estimate how likely individuals move towards these environmental features, differentiating among groups by gender, age, and leptospirosis serostatus. The results indicated that women tended to stay closer to the central stream while avoiding open sewers more than men. Furthermore, individuals who tested positive for leptospirosis tended to avoid open sewers, suggesting that behavioral patterns might influence exposure to risk factors for leptospirosis, hence ensuring more targeted …
Author response:
Reviewer #1 (Public review):
Summary:
The study investigated how individuals living in urban slums in Salvador, Brazil, interact with environmental risk factors, particularly focusing on domestic rubbish piles, open sewers, and a central stream. The study makes use of the step selection functions using telemetry data, which is a method to estimate how likely individuals move towards these environmental features, differentiating among groups by gender, age, and leptospirosis serostatus. The results indicated that women tended to stay closer to the central stream while avoiding open sewers more than men. Furthermore, individuals who tested positive for leptospirosis tended to avoid open sewers, suggesting that behavioral patterns might influence exposure to risk factors for leptospirosis, hence ensuring more targeted interventions.
Strengths:
(1) The use of step selection functions to analyze human movement represents an innovative adaptation of a method typically used in animal ecology. This provides a robust quantitative framework for evaluating how people interact with environmental risk factors linked to infectious diseases (in this case, leptospirosis).
(2) Detailed differentiation by gender and serological status allows for nuanced insights, which can help tailor targeted interventions and potentially improve public health measures in urban slum settings.
(3) The integration of real-world telemetry data with epidemiological risk factors supports the development of predictive models that can be applied in future infectious disease research, helping to bridge the gap between environmental exposure and health outcomes.
Weaknesses:
(1) The sample size for the study was not calculated, although it was a nested cohort study.
We thank Reviewer #1 for highlighting this weakness. We will make sure that this is explained in the next version of the manuscript. At the time of recruiting participants, we found no literature on how to perform a sample size calculation for movement studies involving GPS loggers and associated methods of analysis. Therefore, we aimed to recruit as many individuals as possible within the resource constraints of the study.
(2) The step‐selection functions, though a novel method, may face challenges in fully capturing the complexity of human decision-making influenced by socio-cultural and economic factors that were not captured in the study.
We agree with Reviewer #1 that this model may fail to capture the full breadth of human decision-making when it comes to moving through local environments. We included a section discussing the aspect of violence and how this influences residents’ choices, along with some possibilities on how to record and account for this. Although it is outside of the scope of this study, we believe that coupling these quantitative methods with qualitative studies would provide a comprehensive understanding of movement in these areas.
(3) The study's context is limited to a specific urban slum in Salvador, Brazil, which may reduce the generalizability of its findings to other geographical areas or populations that experience different environmental or socio-economic conditions.
(4) The reliance on self-reported or telemetry-based movement data might include some inaccuracies or biases that could affect the precision of the selection coefficients obtained, potentially limiting the study's predictive power.
We agree that telemetry data has inherent inaccuracies, which we have tried to account for by using only those data points within the study areas. We would like to clarify that there is no self-reported movement data used in this study. All movement data was collected using GPS loggers.
(5) Some participants with less than 50 relocations within the study area were excluded without clear justification, see line 149.
We found that the SSF models would not run properly if there weren’t enough relocations. Therefore, we decided to remove these individuals from the analysis. They are also removed from any descriptive statistics presented.
(6) Some figures are not clear (see Figure 4 A & B).
We will be trying to improve the quality of this image in the next version of the manuscript.
(7) No statement on conflict of interest was included, considering sponsorship of the study.
The conflict-of-interest forms for each author were sent to eLife separately. I believe these should be made available upon publication, but please reach out if these need to be re-sent.
Reviewer #2 (Public review):
Summary:
Pablo Ruiz Cuenca et al. conducted a GPS logger study with 124 adult participants across four different slum areas in Salvador, Brazil, recording GPS locations every 35 seconds for 48 hours. The aim of their study was to investigate step-selection models, a technique widely used in movement ecology to quantify contact with environmental risk factors for exposure to leptospires (open sewers, community streams, and rubbish piles). The authors built two different types of models based on distance and based on buffer areas to model human environmental exposure to risk factors. They show differences in movement/contact with these risk factors based on gender and seropositivity status. This study shows the existence of modest differences in contact with environmental risk factors for leptospirosis at small spatial scales based on socio-demographics and infection status.
Strengths:
The authors assembled a rich dataset by collecting human GPS logger data, combined with field-recorded locations of open sewers, community streams, and rubbish piles, and testing individuals for leptospirosis via serology. This study was able to capture fine-scale exposure dynamics within an urban environment and shows differences by gender and seropositive status, using a method novel to epidemiology (step selection).
Weaknesses:
Due to environmental data being limited to the study area, exposure elsewhere could not be captured, despite previous research by Owers et al. showing that the extent of movement was associated with infection risk. Limitations of step selection for use in studying human participants in an urban environment would need to be explicitly discussed.
The environmental factors used in the study required research teams to visit the sites and map the locations. Given that individuals travelled throughout the city of Salvador, performing this task at a large scale would be unachievable. Therefore, we limited the data to only those points within the study area boundaries to avoid any biases from interactions with unrecorded environmental factors. We will be including a more explicit discussion of the limitations of SSF in urban environmental settings with human participants in the next version of the manuscript.
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