DEVELOPMENT AND CONTENT VALIDITY OF THE HANDWASHING INDEX (HWI)

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1. 

   PREreview

   Oct 11, 2024

   This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/13919839.

   This review is the result of a virtual, collaborative live review discussion organized and hosted by PREreview and JMIR Publications on September 27, 2024. The discussion was joined by 20 people: 2 facilitators, 2 members of the JMIR Publications team, 2 authors, and 14 Live Review participants including 2 who agreed to be named (but did not help compile this final review): Mitchell Collier and Goktug Bender. The authors of this review have dedicated additional asynchronous time over the course of two weeks to help compose this final report using the notes from the Live Review. We thank all participants who contributed to the discussion and made it possible for us to provide feedback on …

   This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/13919839.

   This review is the result of a virtual, collaborative live review discussion organized and hosted by PREreview and JMIR Publications on September 27, 2024. The discussion was joined by 20 people: 2 facilitators, 2 members of the JMIR Publications team, 2 authors, and 14 Live Review participants including 2 who agreed to be named (but did not help compile this final review): Mitchell Collier and Goktug Bender. The authors of this review have dedicated additional asynchronous time over the course of two weeks to help compose this final report using the notes from the Live Review. We thank all participants who contributed to the discussion and made it possible for us to provide feedback on this preprint.

   Summary: 

   The study aims to develop and validate a tool for measuring the frequency of handwashing behavior to improve hygiene practices. Such practices are critical for preventing diseases (especially those transmitted via fecal-oral or nasal routes) and, as seen during the COVID-19 pandemic, handwashing plays a crucial role in the prevention of infection. The primary goal of the study was to create a Handwashing Index (HWI) to effectively track handwashing frequency habits. The researchers adapted the Physical Activity Questionnaire for Adolescents (PAQ-A) to develop the Handwashing Questionnaire (HWQ) and used a structured four-stage process, following Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines, for its development and validation. The authors successfully developed and validated this hand-washing index, employing a well-grounded study plan and methodology. The four-stage process was clearly described, providing a solid foundation for their research. 

   The questionnaire initially contained six questions, which were refined down to four that effectively assessed handwashing practices. These questions were validated using expert input, yielding a strong content validity index (CVI) of 0.9. The validated HWI can categorize individuals into groups like regular and non-regular hand washers, as well as decliners, and offers a simple, practical, and effective tool for tracking handwashing behavior. The conclusions are generally supported by the data, as the content validity results align with the feedback from expert judges. In addition to the validation process, the research also yielded some findings of its own, such as the fact that compliance with regular hand washing was not as high as expected post-pandemic, based on participant self-reporting.

   The HWI can be applied across different settings, including healthcare, public health campaigns, and even individual self-monitoring. Its simplicity makes it suitable for both resource-rich and resource-limited environments. Actual items of the Handwashing Index (HWI) are presented clearly, along with instructions for scoring, making it straightforward for others to reproduce the questionnaire. Reviewers found the novel approach to assessing handwashing practices particularly interesting. They noted that this methodology could be adapted to other behavior-monitoring surveys that may require contextual adjustments. Although the HWI does not assess the method of hand washing, it effectively categorizes compliance with general frequency recommendations. This index could serve as a valuable tool for health professionals and public health officials to track and promote better hand hygiene, especially in low-resource settings.

   Major concerns and feedback

   Alongside its strengths, there exist several ways the study and its reporting could be improved, in areas such as scope and analysis, the survey tool's reproducibility in diverse settings, and clarity in definitions and other aspects. Such improvements would greatly benefit the global community.

   Concerns with techniques/analyses

   • The method section would benefit from more elaboration of the procedure, which will help others to reproduce the same research.

   • Sampling: 

     • The validation process was conducted only with a small sample size of 57 health professionals from Ghana, which could introduce selection bias and limit the generalisability of the findings to a general, global population. It is uncertain whether a survey instrument validated for one research purpose can be modified to an entirely different purpose.

     • The convenience sampling approach raises concerns about selection bias, although the authors acknowledge this. Some data indicates that the sample may not be representative (e.g., trends in age by gender–is the general age of male healthcare workers half that of females? Or did the study fail to recruit more experienced men?

     • It would be helpful to specify how many participants were invited versus how many completed the study to provide context on participation rates.

     • The inclusion of only health professionals limits the applicability of the tool to a general population (and contradicts the stated aim to be used in this broad manner).

   • Scope: 

     • The only aspect of handwashing measured by the questionnaire is frequency. It does not study hand washing methods (e.g., duration, movements, soap used, drying equipment); yet the method by which handwashing is performed can dramatically impact its effectiveness. This limits how well this index can measure compliance with recommended practice, assess hygiene performance, and be an improvement upon existing "guidelines" (e.g., WHO).

     • Given this limit in scope, the authors should make this focus on frequency much more prominent throughout the article (e.g., that word appears only 3 times). This important qualifier could be done in places such as: the name of the index itself (Hand Washing [Frequency] Index), abstract ("there is no validated scale to measure [the frequency of] this habit," and conclusion ("interventions aimed at improving [the frequency of] handwashing in the global community").

   • Measurement:

     • The cutoff point for item scoring appears too low, as a score of 4 is categorized as regular practice, despite the reported highest score being 20.  Furthermore, the upper limit frequency is relatively low, limiting generalizability/  This should be reconsidered, and the response options recategorized to enhance clarity.

     • The use of standard scales (e.g., Likert scale) would be an improvement.

     • The authors should confirm if "average" is the appropriate descriptive statistical measure, or if "median" would be more suitable for the responses.  

     • The authors provide categories for handwashing behaviors, such as "regular," "non-regular," and "decliners," but they do not explain whether the thresholds for these categories are empirically derived or based on expert consensus. Furthermore, the term "decliners" might carry a negative connotation (and thus be under-reported) and could be replaced with a more neutral descriptor, such as "low-frequency hand washers".

     • There is no clear indication that the psychometric properties of the survey instrument were tested, despite mentioning a validation process involving 10 expert judges. This limitation could affect the robustness of the findings.

     • The study is based on self-reported data, which may introduce response bias. The participants might overestimate or underestimate their handwashing behavior. For example, participants may report more frequent handwashing than they actually practice, especially because hand hygiene is a socially desirable behavior. No specific controls are in place to mitigate this bias.

   • Clarity of Instrument (i.e., responses may vary from what is intended if aspects are not clear to  respondents):

     • The questionnaire contained not only a single choice selection but also a rating scale used alongside this. Reviewers were unsure of the reasoning of this or how it would be answered accurately (since it could be unclear to participants).

     • There is no definition of handwashing (e.g., how to do it and how long to do it for). All participants may not have had the same definition of washing their hands in mind when responding.

     • It is unclear what is the difference between 'active handwashing' and regular 'handwashing'. Moreover, even if the authors have a meaningful difference in mind, that would be unlikely to be clearly understood by respondents, and the subjective interpretation of "active" was up to the respondents. Thus, the author statement that the index measures "how active individuals practice" handwashing is insufficiently substantiated.

     • Survey Response Options: The authors should define for respondents 'hardly ever,' 'sometimes,' and 'quite often' to avoid ambiguity. Even if definitions were provided, it is not clear why there is a hybrid between the other quantitative measures and this qualitative one (and the mixture/non-parallel format could be confusing to respondents). The authors might consider changing these response options to quantitative measures, in parallel with the other questions.

   Details for reproducibility of the study

   • The tool's reproducibility could be improved by including more detailed participant selection criteria and clearer descriptions of the handwashing behavior scoring methodology.  

   • The authors do not discuss how the thresholds for defining handwashing categories were derived, which introduces subjectivity and may limit the tool's reliability.  

   • The potential for cultural differences in handwashing behaviors impacting the tool's applicability across populations is not discussed, which could be another limitation for generalisability.

   • Greater clarity on how to answer the questionnaire would improve reproducibility, including a definition on what exactly counts as handwashing, and the difference between active and regular handwashing.

   • Data are not openly available. Whilst the article indicates that data are "available upon reasonable request," this has been proven to be a highly unreliable method of access (particularly with the . qualifier of "reasonable"). Furthermore, data that are not professionally curated are less likely to be usable long-term).

   • The tool could require some improvement in terms of making it reproducible in other settings (for example clarity in definitions etc.) in order to be more useful to a global community.

   Figures, tables, and results

   Recommendations for Improvement: To enhance clarity and readability, the following adjustments should be considered:

   • The tables in the study are generally clear and well-labeled, displaying key data such as participant demographics, scoring categories, and content validity index (CVI) calculations, in an easy-to-understand format. However, including more detailed legends or footnotes for the CVI calculations, participant scoring, and definitions could improve clarity, especially for readers unfamiliar with the validation process.

   • The authors should ensure consistent formatting throughout tables and figures, including the ability to view table numbers and titles when in detail view, and the proximity of the tables to the descriptions. Such changes could better enable readers to follow the tables along with the text.

   • The addition of graphs could provide a good visual comparison of the scores.

   • Table 1 (Socio-demographic Key): While generally clear, this section should include a key or legend explaining the differences between certificate, diploma, and degree.  

   • Table 2: (Clarify 'Active' Handwashing): As mentioned above, the manuscript should specify what 'active' refers to: vigor of handwashing, respondent's daily activity level, or something else.  

   • Table 3: The authors should add a footnote describing the calculation of I-CVI (Item-level Content Validity Index) and S-CVI (Scale-level Content Validity Index).  

   • Tables 3 and 4: Editing and Abbreviation Clarification: The manuscript should provide more detailed footnotes explaining the abbreviations used.  

   • Table 4: Whilst generally concise and straightforward, it could benefit from highlighting the final accepted items, especially for readers who want to focus on the validated items at a glance. A brief legend explaining why item 3 was removed from earlier versions would be helpful.

   • Include a Results Section: The study lacks a dedicated results section, which is essential for presenting findings. 

   Limitations discussed

   • The conclusions are largely supported by the data, as the content validity results and expert feedback align with the development and validation of the Handwashing Index (HWI). The authors appropriately acknowledge many limitations of the study, including the small sample size, the use of self-reported data, and the need for further validation. Yet the conclusion could discuss these limitations in a more nuanced manner, and more explicitly acknowledge how they may affect the generalizability and robustness of the findings. Incorporating these caveats would make the conclusions more balanced.

   • Many important limitations go unmentioned, including:

     • At this stage, the HWI is only validated for content, and its effectiveness as a general tool has not yet been fully established.

     • The potential impact of cultural differences on handwashing behaviors, which may affect the reproducibility and applicability of the index in different populations.  

     • The reasons behind the selection strategy, and biases that might arise from it, should be acknowledged more clearly.

     • The important limitation of measuring only frequency, and not different behaviors when washing hands (e.g., length of time, soap, what was used to dry hands, etc.). Such statements are particularly important given the claim that this Index can improve public health (whereas much of the literature cited in the Introduction is based on measures of quality beyond frequency).

   • Authors could detail their further recommendations regarding future validation studies.

   Ethics

   • Ethical implications arise from the study, particularly regarding post-study education on handwashing for participants identified as "decliners" or "non-regulars," especially given their role in healthcare settings.  

   • The authors should clarify how they communicated with participants. This includes ensuring that participant involvement was not framed in a way that could be perceived as judgmental or evaluative of their professional practice. Nor that their participation (or not) in this study would at all impact their status at their job. This would ensure ethical integrity and transparency in the research process.

   • Although the study mentions following the protocols of the Health Service Review Committee, more details about the ethical approval process would strengthen transparency. 

   Minor concerns and feedback

   Clarification of Terminology, Acronyms, and Descriptions

   • The authors use the key terms of HWQ, HWQ-I, or HWI throughout the manuscript. If each of these terms are indeed important and distinct, the authors should at the outset clearly define each of these terms and explain the distinction, given their similarity. Furthermore, they should introduce the formal name of the proposed standard index more clearly and explicitly. Thereafter, each term should be used consistently throughout the manuscript to prevent confusion.

   •  The manuscript requires clearer definitions of key acronyms at first use; for example, HWQ (Handwashing Questionnaire) is used in the first paragraph, but the acronym is not defined until the methods section.   

   • The authors should provide a definition of handwashing in general. If this ambiguity (including toward respondents) was deliberate, should be explicitly stated.

   • The meaning and differences of terms such as SCVI (Scale-level Content Validity Index) and UA (Universal Agreement) should be explained more thoroughly.  Similarly, CVI calculations and participant scoring need clearer descriptions, especially in Table 3.  

   • The authors' use of the term "monitor" (e.g., "HWI demonstrated excellent content validity, showing its relevance for monitoring handwashing") is not appropriate in this setting, as monitoring indicates a third party overseeing/verifying behavior. 

   Other

   • The authors should organize the introduction to provide context, clearly state the research question(s), and outline the study's objectives. 

   • The main title and short title are mismatched. (HWI versus scale).

   • Further clarification is required on scoring methodologies.  

   • It should be stated in the manuscript the method of survey administration (e.g., paper, website, etc.).

   By addressing these concerns, the manuscript will become more readable, comprehensive, and effective in conveying the study's findings and objectives.

   Suggestions for future work

   • A follow-up study could delve deeper into handwashing practices by assessing respondents' perceived adherence to handwashing protocols (i.e., the method–and not just frequency–of handwashing). This could measure aspects such as duration, availability of soap/water to the respondents, etc.

   • Conducting observational research or surveys to verify their actual handwashing techniques would help to avoid self-reporting bias.

   • While the conclusion reflects the study as designed, before approaching the global community it needs local validation, a greater sample size, and diverse participants across the general population (beyond healthcare professionals, who we assume practice handwashing better than the general population).

   • Given the sample population of healthcare workers, future work could include modifying the questionnaire to focus specifically on that population. The instrument could add questions specific to a healthcare environment, including the environment itself and the characteristics of the respondent (e.g., their role in healthcare). Such changes could make it even more applicable to healthcare workers.

   Concluding remarks

   We thank the authors of the preprint for posting their work openly for feedback. We also thank all participants of the Live Review call for their time and for engaging in the lively discussion that generated this review.

   Competing interests

   Daniela Saderi and Vanessa Fairhurst of the PREreview team were facilitators and organizers of this call. No other competing interests were declared by the reviewers.

   Read the original source
2. 

   PREreview

   Sep 27, 2024

   This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/13849282.

   Does the introduction explain the objective of the research presented in the preprint? Partly The introduction provides a strong justification for the study but lacks depth in terms of background on hand hygiene measurement tools?

   Are the methods well-suited for this research? Somewhat appropriate There is need to provide a clearer rationale for why these specific health professionals were considered experts and how their experience qualifies them to validate the tool. More detail on …

   This Zenodo record is a permanently preserved version of a Structured PREreview. You can view the complete PREreview at https://prereview.org/reviews/13849282.

   Does the introduction explain the objective of the research presented in the preprint? Partly The introduction provides a strong justification for the study but lacks depth in terms of background on hand hygiene measurement tools?

   Are the methods well-suited for this research? Somewhat appropriate There is need to provide a clearer rationale for why these specific health professionals were considered experts and how their experience qualifies them to validate the tool. More detail on the recruitment criteria and methods is necessary for reproducibility. Also, authors should p rovide additional justification for using PAQ-A and why it is suitable for the context of handwashing. Mention alternative instruments that were considered but rejected.

   Are the conclusions supported by the data? Somewhat supported Author should strengthen the conclusion by providing a plan for further psychometric validation of the HWI in different populations and environments. Additionally, include a discussion of how the tool could be integrated into public health interventions.

   Are the data presentations, including visualizations, well-suited to represent the data? Highly appropriate and clear

   How clearly do the authors discuss, explain, and interpret their findings and potential next steps for the research? Somewhat clearly Authors should include a more critical reflection on the limitations of the study, such as geographical and cultural constraints. Also, suggest areas for future research, such as testing the HWI in non-healthcare settings or among populations with limited water access. Similarly, author should discuss how social desirability bias was minimized or could be minimized in future studies using the HWI. Consider suggesting alternative validation methods, such as observational studies.

   Is the preprint likely to advance academic knowledge? Highly likely The preprint manuscript is generally well-written to advance scientific knowledge but would benefit from improvements and simplification in certain areas.

   Would it benefit from language editing? Yes Proofread for clarity, conciseness, and consistency in terminology. For example, terms like "regular hand washers" could be more clearly defined early in the manuscript.

   Would you recommend this preprint to others? Yes, but it needs to be improved Focus on summarizing key contributions and avoid restating information already presented in the results and discussion sections.

   Is it ready for attention from an editor, publisher or broader audience? No, it needs a major revision By addressing issues identified above, the manuscript can be made more robust and better positioned for peer review.

   Competing interests

   The author declares that they have no competing interests.

   Read the original source
3. 

   Version published to 10.1101/2024.07.20.24310756v1 on medRxiv

   Jul 21, 2024