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  1. Evaluation Summary:

    This manuscript uses a species-hybrid model in which functional human white and thermogenic adipose tissues develop in mice. Interestingly, human adipose tissue is fully able to recruit mouse vascular networks and sympathetic innervation during human adipocyte development. These findings provide novel and valuable information about the development of human thermogenic adipose tissue.

    (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

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  2. Reviewer #1 (Public Review):

    The authors employed a unique species-hybrid model wherein implanted human cells from white and thermogenic adipose tissues in nude mice. The authors performed molecular analyses of implanted adipose tissues and made several intriguing observations. One of the notable findings is the expression of MAOA in human adipocytes - this is in contrast to previous findings in mice that MAOA is expressed in macrophages. The cell-autonomous role of MAOA in human adipocytes using the species-hybrid system would add additional significance to this work.

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  3. Reviewer #2 (Public Review):

    This paper provides important new information that will be of high interest to scientists within the field of thermogenic adipose tissue. The application of xenographic implantation of human adipocytes progenitors provides a powerful approach to analyze the development of human thermogenic adipose tissue in mouse. The key conclusions of the manuscript are fully supported by the data presented.

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