Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress
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This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/5855124.
Dalia Murra and colleagues characterized CORT level and behavioral changes in susceptible and resilient animals after social stress, this is a very simple but fundamental study in social defeat field.
The authors first studies whether pre-stress social ratio predict/align with the post-stress and no correlation found in pre-post SI ratio or CORT level.
Then they showed two very interesting findings: first, different coping behavior on the first day actually can predict resiliency, the mice that fight back turn to be resilient, and ones escape during defeat result to be susceptible. Second, the hyper-sensitivity of susceptible mice in Von Frey test, which is a novel feature of the …
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/5855124.
Dalia Murra and colleagues characterized CORT level and behavioral changes in susceptible and resilient animals after social stress, this is a very simple but fundamental study in social defeat field.
The authors first studies whether pre-stress social ratio predict/align with the post-stress and no correlation found in pre-post SI ratio or CORT level.
Then they showed two very interesting findings: first, different coping behavior on the first day actually can predict resiliency, the mice that fight back turn to be resilient, and ones escape during defeat result to be susceptible. Second, the hyper-sensitivity of susceptible mice in Von Frey test, which is a novel feature of the susceptible mice.
This study provides detailed methods and results, followed by a decent discussion, it will shed light on the future study of chronic social defeat field.
Only minor comments here:
Minor:
Figure2A and 5A, since it's 10-day defeat, the timeline of CSDS should be day3-day12?
The blood withdrawal before defeat will also affect the SI test, which eventually affect the result of this paper, this should be mentioned in discussion.
A very interesting question to answer in the following study will be, at which day do the resilient mice start to decrease their fighting and switch to escape? Since the authors only showed day1 and day10 coping behaviors.
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