Correlation between hypophosphatemia and the severity of Corona Virus Disease 2019 patients

  1. Xiaobo Xue
  2. Jing Ma
  3. Yuxia Zhao
  4. Aibin Zhao
  5. Xiaohong Liu
  6. Wei Guo
  7. Fang Yan
  8. Zhixin Wang
  9. Yanqing Guo
  10. Mengbai Fan

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Abstract

Objective

Retrospectively analyze the clinical data of Corona Virus Disease 2019 (COVID-19) patients and explore the value of serum phosphorus level in evaluating the severity and prognosis of the disease.

Methods

COVID-19 patients transferred from the first emergency ward of Taiyuan fourth people’s Hospital from February 8 to March 3, 2020 were enrolled. The information of general conditions, clinical manifestations, laboratory indexes, nucleic acid detection and treatment were collected. The changes of blood phosphorus level and absolute value of lymphocytes in ordinary and severe/critical patients were recorded and compared.

Results

A total of 32 patients with COVID-19 were collected, including 12 cases of common type and 20 cases of severe/critical type. Before treatment, the serum phosphorus levels of the two groups were significantly lower than the normal level, and the serum phosphorus levels of the severe/critical patients were lower than those of the common type patients ( t = 2.767, P < 0.010). After treatment, the serum phosphorus levels of the two groups reached normal, and there was no significant difference between the two groups ( t = 0.231, P >0.819). The level of lymphocytes in severe/critical patients was lower than that in normal patients ( t = 4.636, P < 0.001) before treatment. After treatment, the absolute value of lymphocytes in the two groups reached normal, and there was no significant difference between the two groups ( t =1.208, P =0.237). There was a positive correlation between lymphocytes and serum phosphorus, and the correlation coefficient was 0.479.

Conclusion

hypophosphatemia is related to the severity of COVID-19, and strengthening the monitoring of serum phosphorus level of COVID-19’s severe/critical patients and correcting hypophosphatemia in time are of significance to improve the prognosis.

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  1. ScreenIT

    SciScore for 10.1101/2020.03.27.20040816: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Informed consent was obtained from all individual participants and the study was approved by Taiyuan Forth People’s Hospital Ethics Committee.
    IRB: Informed consent was obtained from all individual participants and the study was approved by Taiyuan Forth People’s Hospital Ethics Committee.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations of this study: 1) the first emergency ward of Taiyuan fourth people’s Hospital is a ward for the treatment of severe/critical COVID 19 patients in Shanxi Province. The small number of samples may affect the statistics and analysis of the results. 2) In the face of sudden outbreaks and life-threatening diseases, no one can use a placebo as a control, so we cannot make sense of exogenous phosphorus supplementation.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1101/2020.03.27.20040816v1 on medRxiv