Investigation of some Immunoproteins in Sera of Patients with Respiratory Disease

This study was designed due to unavailable of chemical parameters reveals and diagnose the respiratory disease and also the difficulty of healing from these chronic disease, therefor the study suggested to measure serum levels of ICAM-1 and IL-1 for them with some of other parameters. Practically, 120 blood samples were collected from 90 patients and 30 healthy persons for comparison, Immune proteins ICAM-1, IL-1 and IgE had measured By ELISA technique and total protein, albumin and calculated globulin by spectrophotometer. The demographic characteristics were collected by outfitted made Questionnaire, high significance differences P = 0.000 for ICAM-1, IL-1 and other proteins was observed when the results of patients group compared with healthy control group. Receiver Operating Characteristic ROC Curve was estimated for ICAM-1 by all groups of patients as compared with healthy by Asthma group sensitivity was 86.6%, specificity = 56.7% AUC = 0.8 and best cut-off point = 251.91 ng/mL, by depending on the sensitivity and AUC it can use the ICAM-1 as excellent discrimination parameter to distinguish asthma.