Euthyroid Sick Syndrome as an Index of Prognosis in Severe COVID-19 Disease
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Background and Objectives: Euthyroid sick syndrome has been observed in severely ill patients and has been found to be an index of prognosis. It has been detected in patients with severe infectious diseases. Euthyroid sick syndrome or non-thyroidal-illness syndrome has been observed in severe COVID-19 infection. Prognostic indicators of the outcome of severe COVID-19 disease are important for the prognosis of individual as well as groups of patients. The aim was to identify euthyroid sick syndrome in patients admitted for severe COVID-19 disease and its relationship to disease severity and outcome. Materials and Methods: In a cohort of patients admitted to hospital for severe COVID-19 disease thyroid function was evaluated by measuring TSH, FreeT3 (FT3) and FreeT4 (FT4) levels. Results: In this cohort euthyroid sick syndrome was diagnosed in 57.1% of the patients. The presence of euthyroid sick syndrome was related to disease severity and disease outcome. FT3 levels were inversely related to CRP levels. Conclusions: In conclusion, euthyroid sick syndrome may be observed in severe COVID-19 disease and is related to disease severity. It appears to be an index of adverse outcome.