Advanced lesion symptom mapping analyses and implementation as BCBtoolkit

  1. C Foulon
  2. L Cerliani
  3. S Kinkingnéhun
  4. R Levy
  5. C Rosso
  6. M Urbanski
  7. E Volle
  8. M Thiebaut de Schotten

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Abstract

Background

Patients with brain lesions provide a unique opportunity to understand the functioning of the human mind. However, even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. Similarly, function emerges from the interaction between brain areas rather than their sole activity. For instance, category fluency requires the association between executive, semantic and language production functions.

Findings

Here we provide, for the first time, a set of complementary solutions to measure the impact of a given lesion upon the neuronal circuits. Our methods, which were applied to 37 patients with a focal frontal brain lesion, revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted category fluency performance. The directly disconnected regions corresponded to areas that are classically considered as functionally engaged in verbal fluency and categorization tasks. These regions were also organized into larger directly and indirectly disconnected functional networks, including the left ventral fronto-parietal network, whose cortical thickness correlated with performance on category fluency.

Conclusions

The combination of structural and functional connectivity together with cortical thickness estimates reveals the remote effects of brain lesions, provide for the identification of the affected networks and strengthen our understanding of their relationship with cognitive and behavioural measures. The methods presented are available and freely accessible in the BCBtoolkit as supplementary software [1].

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  1. GigaScience

    Now published in GigaScience doi: 10.1093/gigascience/giy004

    C Foulon aBrain Connectivity and Behaviour Group, Sorbonne Universities, Paris France.bFrontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France.cCentre de Neuroimagerie de Recherche CENIR, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteORCID record for C FoulonFor correspondence: hd.chrisfoulon@gmail.com michel.thiebaut@gmail.comL Cerliani aBrain Connectivity and Behaviour Group, Sorbonne Universities, Paris France.bFrontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France.cCentre de Neuroimagerie de Recherche CENIR, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteS Kinkingnéhun aBrain Connectivity and Behaviour Group, Sorbonne Universities, Paris France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteR Levy bFrontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteC Rosso cCentre de Neuroimagerie de Recherche CENIR, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.dAbnormal Movements and Basal Ganglia team, Inserm U 1127, CNRS UMR 7225, Sorbonne Universities, UPMC Univ Paris 06, Institut du Cerveau et de la Moelle épinière, ICM, Paris, FranceeAPHP, Urgences Cérébro-Vasculaires, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteM Urbanski aBrain Connectivity and Behaviour Group, Sorbonne Universities, Paris France.bFrontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France.fMedicine and Rehabilitation Department, Hôpitaux de Saint-Maurice, Saint-Maurice, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteE Volle aBrain Connectivity and Behaviour Group, Sorbonne Universities, Paris France.bFrontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France.cCentre de Neuroimagerie de Recherche CENIR, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteM Thiebaut de Schotten aBrain Connectivity and Behaviour Group, Sorbonne Universities, Paris France.bFrontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France.cCentre de Neuroimagerie de Recherche CENIR, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.Find this author on Google ScholarFind this author on PubMedSearch for this author on this siteFor correspondence: hd.chrisfoulon@gmail.com michel.thiebaut@gmail.com

    A version of this preprint has been published in the Open Access journal GigaScience (see paper https://doi.org/10.1093/gigascience/giy004 ), where the paper and peer reviews are published openly under a CC-BY 4.0 license.

    These peer reviews were as follows:

    Reviewer 1: http://dx.doi.org/10.5524/REVIEW.101000 Reviewer 2: http://dx.doi.org/10.5524/REVIEW.101001

  2. Version published to 10.1101/133314v4 on bioRxiv
  3. Version published to 10.1101/133314v3 on bioRxiv
  4. Version published to 10.1101/133314v2 on bioRxiv
  5. Version published to 10.1101/133314v1 on bioRxiv