NanoSim: nanopore sequence read simulator based on statistical characterization
This article has been Reviewed by the following groups
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- Evaluated articles (GigaScience)
Abstract
Motivation:
In 2014, Oxford Nanopore Technologies (ONT) announced a new sequencing platform called MinION. The particular features of MinION reads – longer read lengths and single-molecule sequencing in particular – show potential for genome characterization. As of yet, the pre-commercial technology is exclusively available through early-access, and only a few datasets are publically available for testing. Further, no software exists that simulates MinION platform reads with genuine ONT characteristics.
Results:
In this article, we introduce NanoSim, a fast and scalable read simulator that captures the technology-specific features of ONT data, and allows for adjustments upon improvement of nanopore sequencing technology.
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Now published in GigaScience doi: 10.1093/gigascience/gix010
A version of this preprint has been published in the Open Access journal GigaScience (see paper https://doi.org/10.1093/gigascience/gix010 ), where the paper and peer reviews are published openly under a CC-BY 4.0 license.
These peer reviews were as follows:
Reviewer 1: http://dx.doi.org/10.5524/REVIEW.100575 Reviewer 2: http://dx.doi.org/10.5524/REVIEW.100577
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