Clinical and Microbiological Characteristics of Rare Pathogens Causing Bacteremia in Patients Admitted to a Tertiary Care Centre in Northern India
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Introduction: The use of newer diagnostic and therapeutic procedures, broad-spectrum antibiotics, and, chemotherapy increases susceptibility to bacteremia. Rise of new bacterial pathogens raises innumerable concerns like virulence capacity, and susceptibility profiles of these organisms. Hypothesis/Gap Statement: Information about the incidence and risk factors of bacteremia caused by rare pathogens from India is limited. Aim: We conducted this study to identify the risk factors and underlying conditions predisposing to bacteremia by rare pathogens and analyze the antibiotic resistance pattern of the isolates. Methodology: This retrospective study was performed on 64 rare isolates collected from blood culture from January 2022 to December 2022. All clinical and laboratory data was obtained from laboratory registers and the electronic information system and later analyzed by using SPSS statistical software (IBM SPSS version 20, Armonk, N.Y.). Result: Sixty-four rare pathogenic gram-negative bacteria (GNB) were identified from blood culture. Mean age of patients was 36.60 ± 21.83 years, with 56.25% (36/64, 56.25%) men. Malignancies (25/64, 39.06%) were the most common comorbidity in the patients. Burkholderia cenocepacia (21/64, 32.81%) was the most common microorganism followed by Ochrobactrum spp (16/64, 25.0%). During hospitalization, 17.19% (11/64, 17.19%) patients had indwelling catheterization, 40.63% (26/6, 40.63%) patients underwent surgical procedures and 32.81% (21/64, 32.81%) patients had chemo port in-situ. Out of 64 patients, 13 (13/64, 20.31%) patients died due to the direct effect of bacteremia caused by these isolates. Conclusion: This study represents the rare pathogens identified from bloodstream infections and evaluates their susceptibility pattern to aid the clinicians’ knowledge.
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Thank you for submitting your manuscript to Access Microbiology. Following careful consideration, I regret to inform you that your manuscript is not suitable for publication in Access Microbiology and your manuscript is no longer under consideration. Thank you for including the definition of a rare bacteria in your revised manuscript, however, the current definition based on colony morphology remains a point of contention. The variability in the interpretation of colony characteristics among different individuals raises concerns about the reliability and reproducibility of this criterion. Moreover, the information provided on rare bacteria, although comprehensive, lacks a comparative analysis with the common bacteria. This comparison is crucial for clinicians to assess the clinical significance of infections caused by rare bacteria in …
Thank you for submitting your manuscript to Access Microbiology. Following careful consideration, I regret to inform you that your manuscript is not suitable for publication in Access Microbiology and your manuscript is no longer under consideration. Thank you for including the definition of a rare bacteria in your revised manuscript, however, the current definition based on colony morphology remains a point of contention. The variability in the interpretation of colony characteristics among different individuals raises concerns about the reliability and reproducibility of this criterion. Moreover, the information provided on rare bacteria, although comprehensive, lacks a comparative analysis with the common bacteria. This comparison is crucial for clinicians to assess the clinical significance of infections caused by rare bacteria in relation to common bacteria. Finally, the discussion section is also inadequate, instead repeating the results which limits the depth of discussion. I am sorry that we cannot be more positive on this occasion and thank you for the opportunity to consider your work.
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Thank you for submitting your manuscript for publication in Access Microbiology. However, before this manuscript can be considered for peer review further information is required. 1. How do you define a rare bacteria? In this manuscript, you state that you selected 64 rare isolates, but on what basis? 2. How many cases of bacteremia in total were there during Jan 22 – Dec 22? 3. What percentage of the total cases were caused by the rare bacteria included in this study? E.g. what % of the total cases were caused by Burkholderia etc
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