Listeria innocua infection in an old case of total knee replacement – an unusual case report
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Prosthetic implant-associated arthritis due to Listeria is mostly reported for Listeria monocytogenes . Here, we describe a patient who underwent total knee replacement 12 years ago and presented with pain, tenderness, redness and local rise in temperature in the right knee. Purulent fluid was aspirated. Upon microbiological analysis, culture yielded Listeria innocua . L. innocua is rare. Listeria is not reported as a contaminant and routine cultures may be negative. Because of the long interval between surgery and the onset of symptoms, clinical suspicion, radiological investigations and analysing multiple samples are of immense help.
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I am pleased to tell you that your article has now been accepted for publication in Access Microbiology.
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This study would be a valuable contribution to the existing literature. The reviewers have highlighted minor concerns with the work presented. Please ensure that you address their comments.
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Comments to Author
In addition to the review comments below, please consider these comments: Listeria is widely accepted as a pathogen. I suggest the authors amend the claim it believed to be a pathogen. Also, there are many recent, high quality Listeria references which could be used to support general microbiology in your introduction. At line 51 the patient is referred to as "her". If the patient is a woman, it might better to describe the patient as female in the first line of the case. Line 52 I suggest changing "total count" to total cell count Please include a brief description of what bact-alert is. Line 59 "patient was treated conservatively" please include a sentence describing the reasoning for a conservative treatment. This may be useful for future similar cases. Please also provide detail of the …
Comments to Author
In addition to the review comments below, please consider these comments: Listeria is widely accepted as a pathogen. I suggest the authors amend the claim it believed to be a pathogen. Also, there are many recent, high quality Listeria references which could be used to support general microbiology in your introduction. At line 51 the patient is referred to as "her". If the patient is a woman, it might better to describe the patient as female in the first line of the case. Line 52 I suggest changing "total count" to total cell count Please include a brief description of what bact-alert is. Line 59 "patient was treated conservatively" please include a sentence describing the reasoning for a conservative treatment. This may be useful for future similar cases. Please also provide detail of the dosage of chosen antibiotics. Line 62 please also detail the time of second follow-up Table 1: clarity of the table would benefit from the headings being emboldened. Discussion: please reformat so all of the discussion is aligned in the same manner. Line 83 rephrase "less suspected of," to rarely suspected Line 87 change "there is" to there are Abbreviations are used inconsistently throughout. Please ensure to define all abbreviations at the first use. Figure legends are absent. Please describe the figure in a legend for figure 1. Please italicise all microbial names.
Please rate the quality of the presentation and structure of the manuscript
Satisfactory
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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Comments to Author
This case report is the first case of prosthetic joint infection due to L. innocua for such, it has great scientific value. However, the punctuation, sentence structure, and syntax of some of the paragraphs make it difficult to follow. In general: -The definition of abbreviations should be included when using them for the first time. -Consider using italics for scientific names. -Check grammar, punctuation, syntax, and sentence structure. -Abstract should be included in numeration as #2. Update numeration of subtitles. -Consider combining figure and table under #6. Abstract: -Check grammar, punctuation, syntax, and sentence structure. Introduction: -Line 31-33: Sentence is not correct/clear. 1) From Listeria genus only L. monocytogenes and L. ivanovii are considered pathogens; 2) Meningitis and …
Comments to Author
This case report is the first case of prosthetic joint infection due to L. innocua for such, it has great scientific value. However, the punctuation, sentence structure, and syntax of some of the paragraphs make it difficult to follow. In general: -The definition of abbreviations should be included when using them for the first time. -Consider using italics for scientific names. -Check grammar, punctuation, syntax, and sentence structure. -Abstract should be included in numeration as #2. Update numeration of subtitles. -Consider combining figure and table under #6. Abstract: -Check grammar, punctuation, syntax, and sentence structure. Introduction: -Line 31-33: Sentence is not correct/clear. 1) From Listeria genus only L. monocytogenes and L. ivanovii are considered pathogens; 2) Meningitis and bacteremia caused by Listeria are different clinical manifestations of Listeriosis. Case Presentation: -Consider including a description of the patient's relevant demographic info (without any details that could lead to the identification of the patient). -Please define abbreviations. -Line 39-44: Consider reordering the paragraph (Starting with All relevant medical history of the patient -Include the total knee replacement in the first sentence, and dates when possible. Continue with the symptoms and signs). -Line 44-51: Include dates in the text and reference Table 1. -Line 55: Include the media used for subcultures. -Figure 1: Consider including a detailed explanation of the figure (Figures and tables should be broadly comprehensible without reference to the text). -Table 1: Consider including row/column titles indicating the Visit # (i.e. Visit #1), Date, Symptoms, Exams/Diagnosis, Treatment. Include abbreviations as footnotes. Discussion: -Check grammar, punctuation, syntax, and sentence structure. -Paragraph 1: Check format. -Line 70-72: Check for clarity. Consider re-write the sentence. -Line 74-77: Consider re-write the sentence. It is not accurate and it is very confusing. Listeriosis is not a "rare bacterial disease". Also, sepsis and meningoencephalitis are not causes of listeriosis. -Line 82-85: Consider re-write the sentence. -Line 90-93: Consider re-write the paragraph.
Please rate the quality of the presentation and structure of the manuscript
Poor
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
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