Emergence of specific binding and catalysis from a designed generalist binding protein
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The hit rate for discovering fragments bound to ABLE (18%) is similar to the reported hit rates of 7% and 19% for Nsp3 macrodomain of SARS-CoV-2 and Chikungunya virus, respectively, using the same fragment library and screening method
Hi, I'm curious which proteins have unusually low or high hit rates, and what can be learned from that in terms of evolutionary history or plasticity?
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