Centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium

  1. Jennifer Sheridan
  2. Aline Grata
  3. Julia Dorr
  4. Eve E. Suva
  5. Enzo Bresteau
  6. Linus R. Mitchell
  7. Osama Hassan
  8. Brian Mitchell

Reviewed by

Read the full article See related articles

Discuss this preprint

Start a discussion What are Sciety discussions?

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1016/j.ydbio.2025.05.011
  2. Arcadia Science

    We generated a version of AK7 lacking the DPY30 domain and found that the ciliary localization is dramatically reduced, suggesting that this domain is important for its ciliary localization

    Would be interesting to also have a control that lacks a different domain (the kinase, LID, or NMP domains) to see if the DPY30 domain containing deletion mutants can still localize to cilia to exclude the possibility of global misfolding, or other regions being responsible for ciliary localization.

  3. Version published to 10.1101/2023.07.25.550535 on bioRxiv