VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

  1. Fatima Rizvi
  2. Yu-Ri Lee
  3. Ricardo Diaz-Aragon
  4. Pushpinder S. Bawa
  5. Juhoon So
  6. Rodrigo M. Florentino
  7. Susan Wu
  8. Arianna Sarjoo
  9. Emily Truong
  10. Anna R. Smith
  11. Feiya Wang
  12. Elissa Everton
  13. Alina Ostrowska
  14. Kyounghwa Jung
  15. Ying Tam
  16. Hiromi Muramatsu
  17. Norbert Pardi
  18. Drew Weissman
  19. Alejandro Soto-Gutierrez
  20. Donghun Shin
  21. Valerie Gouon-Evans

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Abstract

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  1. Version published to 10.1016/j.stem.2023.10.008
  2. preLights

    Excerpt

    Steer clear of steatosis – VEGFA lipid nanoparticles (LNPs) drive BEC-hepatocyte conversion, an alternative pathway for liver regeneration.

  3. Version published to 10.1101/2023.04.17.537186v1 on bioRxiv