A 3D-printed handheld device for quick citrus tissue lysis and nucleic acid extraction

  1. Chia-Wei Liu
  2. Brent Kalish
  3. Sohrab Bodaghi
  4. Georgios Vidalakis
  5. Hideaki Tsutsui

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Abstract

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  1. Version published to 10.1016/j.sampre.2025.100199
  2. Arcadia Science

    The results prove that 1-minute mechanical maceration using such a small handheld device can perform almost equivalently in sample lysis to manual grinding using a mortar and pestle.

    Really great reading about this device! Has anyone tried using it for nucleus extractions of algae? We have used a modified version of this protocol where we cryo-grind Chlamydomonas with a mortar and pestle, but found it to be laborious and inconsistent. I'd imagine you'd need to make significant modifications to cool the system, though that might be beneficial due to the heat that is generated from the motor

  3. Version published to 10.1101/2024.08.26.609775 on bioRxiv